216854-27-2Relevant academic research and scientific papers
HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0330; 0333, (2016/04/20)
The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists
Wilcoxen, Keith,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.,Chen, Chen
, p. 3367 - 3370 (2007/10/03)
3-Phenylpyrazolo[4,3-b]pyridines were synthesized via a cyclization of 4-amino-3-phenylpyrazoles 11-13 with ethyl acetoacetate. These compounds were found to be potent CRF1 antagonists. The 2-alkylpyrazolo[4,3-b]pyridines were more polar but le
A convenient one-pot synthesis of 4-amino-3-arylpyrazoles from α- phthaloylaminoacetophenones
Chen, Chen,Wilcoxen, Keith,McCarthy, James R.
, p. 8229 - 8232 (2007/10/03)
Condensation of α-phthaloylaminoacetophenones 1a-c with N,N- dimethylformamide dimethyl acetal afforded the novel enamines 3a-c. Cyclization of 3 with hydrazine, alkylhydrazine or phenylhydrazine salts (4a- d) gave 4-phthaloylamino-3-arylpyrazoles 7-9 in
