216854-35-2Relevant academic research and scientific papers
Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists
Wilcoxen, Keith,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.,Chen, Chen
, p. 3367 - 3370 (2003)
3-Phenylpyrazolo[4,3-b]pyridines were synthesized via a cyclization of 4-amino-3-phenylpyrazoles 11-13 with ethyl acetoacetate. These compounds were found to be potent CRF1 antagonists. The 2-alkylpyrazolo[4,3-b]pyridines were more polar but le
A convenient one-pot synthesis of 4-amino-3-arylpyrazoles from α- phthaloylaminoacetophenones
Chen, Chen,Wilcoxen, Keith,McCarthy, James R.
, p. 8229 - 8232 (2007/10/03)
Condensation of α-phthaloylaminoacetophenones 1a-c with N,N- dimethylformamide dimethyl acetal afforded the novel enamines 3a-c. Cyclization of 3 with hydrazine, alkylhydrazine or phenylhydrazine salts (4a- d) gave 4-phthaloylamino-3-arylpyrazoles 7-9 in
