21629-52-7 Usage
Description
4,5-Dichloro-2,8-dimethylquinoline, with the molecular formula C12H10Cl2N, is a yellowish crystalline solid that serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals. It has demonstrated antimalarial and antiproliferative activities, positioning it as a promising candidate for drug development. Furthermore, its fluorescent properties make it suitable for applications in medical and biological research.
Uses
Used in Pharmaceutical Industry:
4,5-Dichloro-2,8-dimethylquinoline is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its antimalarial and antiproliferative properties to contribute to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 4,5-dichloro-2,8-dimethylquinoline is utilized as an intermediate in the production of agrochemicals, potentially aiding in the development of pesticides or other agricultural products.
Used as a Fluorescent Dye in Medical and Biological Research:
4,5-Dichloro-2,8-dimethylquinoline is employed as a fluorescent dye in medical and biological applications, capitalizing on its optical properties to enhance imaging and detection in research settings.
Used in Analytical Chemistry as a Fluorescent Probe:
4,5-DICHLORO-2,8-DIMETHYLQUINOLINE is utilized as a fluorescent probe in analytical chemistry, where its fluorescent characteristics can be harnessed for sensitive detection and analysis of various substances.
Used as a Corrosion Inhibitor:
4,5-Dichloro-2,8-dimethylquinoline has been studied for its potential as a corrosion inhibitor, suggesting that it could be used in industrial applications to protect materials from degradation.
Check Digit Verification of cas no
The CAS Registry Mumber 21629-52-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,2 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21629-52:
(7*2)+(6*1)+(5*6)+(4*2)+(3*9)+(2*5)+(1*2)=97
97 % 10 = 7
So 21629-52-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H9Cl2N/c1-6-3-4-8(12)10-9(13)5-7(2)14-11(6)10/h3-5H,1-2H3
21629-52-7Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.