21629-52-7 Usage
General Description
4,5-Dichloro-2,8-dimethylquinoline is a chemical compound with the molecular formula C12H10Cl2N. It is a yellowish crystalline solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4,5-DICHLORO-2,8-DIMETHYLQUINOLINE has been shown to exhibit antimalarial and antiproliferative activities, making it a potential candidate for drug development. It is also used as a fluorescent dye in various medical and biological applications. Additionally, 4,5-dichloro-2,8-dimethylquinoline has been studied for its potential as a corrosion inhibitor and as a fluorescent probe in analytical chemistry. However, its toxicological properties and environmental effects are not well characterized, and further research is needed to assess its safety and potential risks.
Check Digit Verification of cas no
The CAS Registry Mumber 21629-52-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,2 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21629-52:
(7*2)+(6*1)+(5*6)+(4*2)+(3*9)+(2*5)+(1*2)=97
97 % 10 = 7
So 21629-52-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H9Cl2N/c1-6-3-4-8(12)10-9(13)5-7(2)14-11(6)10/h3-5H,1-2H3
21629-52-7Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.