21629-50-5 Usage
Uses
Used in Pharmaceutical Industry:
5-CHLORO-2,8-DIMETHYL-4-QUINOLINOL is used as an antibacterial and antifungal agent for the treatment of urinary tract infections. It is effective against a wide range of pathogens, including Escherichia coli, Staphylococcus aureus, and Candida species, due to its ability to inhibit their growth in the urinary tract.
5-CHLORO-2,8-DIMETHYL-4-QUINOLINOL's broad-spectrum activity, coupled with its generally well-tolerated nature and low incidence of side effects such as gastrointestinal upset and skin reactions, positions nitroxoline as a preferred choice for managing urinary tract infections. Its availability in oral formulations further enhances its accessibility and convenience for patients.
Moreover, the low resistance development associated with nitroxoline's use underscores its enduring value in the treatment of urinary tract infections, especially in an era where antibiotic resistance is a growing concern. As such, nitroxoline continues to be an essential component in the arsenal against bacterial and fungal infections, highlighting its significance in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 21629-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,2 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21629-50:
(7*2)+(6*1)+(5*6)+(4*2)+(3*9)+(2*5)+(1*0)=95
95 % 10 = 5
So 21629-50-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H10ClNO/c1-6-3-4-8(12)10-9(14)5-7(2)13-11(6)10/h3-5H,1-2H3,(H,13,14)
21629-50-5Relevant academic research and scientific papers
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
