216978-33-5Relevant academic research and scientific papers
Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations
Bowie, Alfred L.,Trauner, Dirk
supporting information; experimental part, p. 1581 - 1586 (2009/07/17)
A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium- catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lact
Enantioselective synthesis of a hindered furyl substituted allyl alcohol intermediate: A case study in asymmetric synthesis
Pihko, Ainoliisa J.,Lundell, Katri,Kanerva, Liisa,Koskinen, Ari M.P.
, p. 1637 - 1643 (2007/10/03)
In the course of the synthesis of the DEFG ring system of cneorin C 1, we were faced with the task of preparing the furyl substituted allyl alcohol 5 enantioselectively. Several different methods starting from enantioselective zinc-mediated alkylations were attempted, but none of them proved entirely satisfactory. The solution turned out to be enzymatic kinetic resolution through a highly enantioselective (E>300) acylation in the presence of Candida antarctica lipase A.
A tandem radical macrocyclisation-transannular cyclisation approach towards the taxanes
Hitchcock, Stephen A.,Houldsworth, Stephen J.,Pattenden, Gerald,Pryde, David C.,Thomson, Nicholas M.,Blake, Alexander J.
, p. 3181 - 3206 (2007/10/03)
Separate treatment of the iodotrienedione 19 and the iododienynedione 38 with Bu3SnH-AIBN produces the corresponding taxane ring systems 25 (25-30%) and 56 (50-60%) respectively by way of tandem radical macrocyclisation-radical transannular cyc
