141874-39-7Relevant academic research and scientific papers
Enantioselective synthesis of a hindered furyl substituted allyl alcohol intermediate: A case study in asymmetric synthesis
Pihko, Ainoliisa J.,Lundell, Katri,Kanerva, Liisa,Koskinen, Ari M.P.
, p. 1637 - 1643 (2007/10/03)
In the course of the synthesis of the DEFG ring system of cneorin C 1, we were faced with the task of preparing the furyl substituted allyl alcohol 5 enantioselectively. Several different methods starting from enantioselective zinc-mediated alkylations were attempted, but none of them proved entirely satisfactory. The solution turned out to be enzymatic kinetic resolution through a highly enantioselective (E>300) acylation in the presence of Candida antarctica lipase A.
A tandem radical macrocyclisation-transannular cyclisation approach towards the taxanes
Hitchcock, Stephen A.,Houldsworth, Stephen J.,Pattenden, Gerald,Pryde, David C.,Thomson, Nicholas M.,Blake, Alexander J.
, p. 3181 - 3206 (2007/10/03)
Separate treatment of the iodotrienedione 19 and the iododienynedione 38 with Bu3SnH-AIBN produces the corresponding taxane ring systems 25 (25-30%) and 56 (50-60%) respectively by way of tandem radical macrocyclisation-radical transannular cyc
Preparation of C-4 alkylated dideoxyribosides: Potential precursors to a novel series of nucleosides
Lipshurtz,Sharma,Dimock,Behling
, p. 191 - 195 (2007/10/02)
Methallyl alcohol can be converted in five simple operations (alkylation, epoxidation, alkynyl-coupling, hydroboration/oxidation, cyclization) to C-5 protected, chiral, non-racemic dideoxyribosides containing an alkyl appendage at the C-4 site.
