21724-88-9

Upstream product

• 941-69-5 N-phenyl-maleimide 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 637-87-6 1-Chloro-4-iodobenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 124-38-9 carbon dioxide 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 106-47-8 4-chloro-aniline 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbonylative Cyclization of Terminal Alkynes and Anilines to 3-Substituted Maleimides

Herein, we describe an interesting palladium-catalyzed protocol for the carbonylative synthesis of 3-substituted maleimides. By annulation of simple anilines with terminal alkynes under carbon monoxide pressure, the desired 3-substituted maleimides can be

Palladium-catalyzed aerobic oxidative carbonylation of alkynes with amines: a general access to substituted maleimides

A catalytic oxidative carbonylation reaction was developed for the synthesis of polysubstituted maleimides from alkynes and amines with air as a green oxidant. This novel transformation proceeds in the presence of palladium chloride without the need for expensive ligands or additives and has a broad substrate scope affording a variety of maleimides in good to high yields.

Cu/Ag-Cocatalyzed Aerobic Oxidative Amination and CuCl2-Mediated Aerobic Oxidative Chloroamination of Maleimides

An efficient Cu(OAc)2/Ag2CO3-cocatalyzed approach for the synthesis of 3-aminomaleimides and 3-amino-4-indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl2leads to the formation of chloroamination products such as 3-amino-4-chloromaleimides by a radical-type mechanism.

Synthesis of 2-arylmaleimides via the Heck reaction

The Heck reaction of maleimides with aryl iodides in the presence of PdCl2(MeCN)2, Bu4NCl and HCOOK affords the corresponding 2-arylmaleimides in moderate yields.