217312-98-6

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 100159-47-5 1-(benzyloxy)pyrazole 

Downstream Products

• 229171-07-7 1-(benzyloxy)-4-iodo-1H-pyrazole 
• 350609-46-0 1-benzyloxy-5-(2-fluorophenyl)-4-iodo-pyrazole 
• 439100-78-4 diethyl 2-[1-benzyloxy-5-(2-fluorophenyl)-pyrazol-4-yl]-2-tert-butoxycarbonylamino-malonate 
• 439100-99-9 diethyl 2-tert-butoxycarbonylamino-2-[1-hydroxy-5-(2-fluorophenyl)-pyrazol-4-yl]-malonate 

Relevant academic research and scientific papers

Synthesis of 1-hydroxypyrazole glycine derivatives

A series of novel α-amino acids containing the 1-hydroxypyrazole ring has been prepared by addition of organomagnesium or organolithium intermediates to diethyl N-Boc-iminomalonate as an electrophilic glycine equivalent. Electrophiles, aryl and heteroaryl

Novel anionic annelation tactics for construction of fused heteroaromatic frameworks. 1. Synthesis of 4-substituted pyrazolo[4,3-c]quinolines, 9-substituted pyrazolo[3,4-c]quinolines, and 1,4-dihydrochromeno[4,3-c]pyrazoles

4-Substituted pyrazolo[4,3-c]quinolines 4a-i and 6a-b were prepared from pyrazole 3 whereas 9-substituted pyrazolo[3,4-c]quinolines 9a-d and 17 were prepared from pyrazole 13 utilizing anionic annelation techniques. 1,4-Dihydrochromeno[4,3- c]pyrazoles 7a-c were accessed from pyrazole 3, extending the method for the synthesis of 4a-i.

Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling

Palladium(0) catalyzed cross-coupling of 1-(benzyloxy)pyrazol-5-ylzinc halides 3a,b, prepared by transmetalation of 1-(benzyloxy)-5-lithiopyrazole (2), with acyl chlorides produced 5 acyl-1-(benzyloxy)pyrazoles 4a-d in high yields. Similar coupling of the