217313-05-8Relevant academic research and scientific papers
Synthesis of a new analogue of BINOL based on a homodimer of substituted 1-hydroxypyrazole
Rist,Begtrup
, p. 1566 - 1568 (2001)
A new potential ligand for asymmetric synthesis, based on a homodimer of 1-hydroxypyrazole, has been synthesized. The chemistry involved lithiation, iodine-magnesium exchange, magnesium-zinc exchange, and cross-coupling reactions. In a preliminary study, the chemical activity of the ligand as a titanium(IV) complex was investigated in the addition of diethyl zinc to benzaldehyde. Its activity was comparable to the corresponding BINOL-Ti(IV) complex.
Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling
Kristensen, Jesper,Begtrup, Mikael,Vedso, Per
, p. 1604 - 1608 (2007/10/03)
Palladium(0) catalyzed cross-coupling of 1-(benzyloxy)pyrazol-5-ylzinc halides 3a,b, prepared by transmetalation of 1-(benzyloxy)-5-lithiopyrazole (2), with acyl chlorides produced 5 acyl-1-(benzyloxy)pyrazoles 4a-d in high yields. Similar coupling of the
