365562-82-9Relevant academic research and scientific papers
Synthesis of a new analogue of BINOL based on a homodimer of substituted 1-hydroxypyrazole
Rist,Begtrup
, p. 1566 - 1568 (2007/10/03)
A new potential ligand for asymmetric synthesis, based on a homodimer of 1-hydroxypyrazole, has been synthesized. The chemistry involved lithiation, iodine-magnesium exchange, magnesium-zinc exchange, and cross-coupling reactions. In a preliminary study, the chemical activity of the ligand as a titanium(IV) complex was investigated in the addition of diethyl zinc to benzaldehyde. Its activity was comparable to the corresponding BINOL-Ti(IV) complex.
