2174-12-1Relevant academic research and scientific papers
Vitamin D3 purification method
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Paragraph 0030; 0032; 0033; 0034, (2021/03/13)
The invention discloses a vitamin D3 purification method which comprises the following steps: a1, mixing organic amine, a first organic solvent, vitamin D3 oil and aryl chloride to react, and then adding water to stop the reaction; a2, washing the product obtained in the step a1 with water, performing drying and filtering, carrying out reduced pressure distillation, performing dissolving, carryingout secondary reduced pressure distillation, carrying out cooling and crystallizing; b1, dissolving vitamin D3 methyl benzoate in methanol, and dropwise adding a strong alkaline solution to perform reacting; b2, carrying out reduced pressure distillation on the substance obtained in the step b1, then carrying out liquid separation, washing an organic phase with water, and carrying out drying, filtering, carrying out secondary reduced pressure distillation, dissolving, cooling and recrystallizing; c1, dissolving the vitamin D3 crude product in a third organic solvent, and then performing stirring for decolorization; and c2, filtering the product obtained in the step c1, carrying out reduced pressure distillation on the filtrate, and carrying out dissolving, cooling, recrystallizing, filtering, and drying to obtain the vitamin D3. The vitamin D3 purified by the purification method disclosed by the invention has the advantages of higher purity, lower harmful impurity content and higher stability.
