217433-67-5Relevant articles and documents
Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst
Jaszczewska-Adamczak, Joanna A.,Mlynarski, Jacek
supporting information, p. 4247 - 4255 (2021/07/17)
Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).
Facial selectivity and stereospecificity in the (4 + 3) cycloaddition of epoxy enol silanes
Lo, Brian,Chiu, Pauline
, p. 864 - 867 (2011/05/06)
The scope of the (4 + 3) cycloaddition using epoxy enol silanes has been examined. Unhindered and nucleophilic dienes react to give the highest yields, but hindered dienes give rise to higher diastereoselectivities. Notably, the cycloaddition shows facial
Amino-acid-mediated epoxidation of α,β-unsaturated ketones by hydrogen peroxide in aqueous media
Kim, Juhyun,Jung, Suhyun,Park, Seongsoon,Park, Sojung
experimental part, p. 2866 - 2868 (2011/06/21)
Amino acids, such as arginine and lysine, can be used as an efficient catalyst in the epoxidation of α,β-unsaturated ketones with aqueous hydrogen peroxide. Up to >99% conversion was obtained in the reaction toward 11 α,β-unsaturated ketones.
