21749-83-7

Basic information

• Product Name: 2-(4-METHOXYPHENYL)-2-PHENYLACETIC ACID
• Synonyms: 2-(4-METHOXYPHENYL)-2-PHENYLACETIC ACID;(4-Methoxyphenyl)(phenyl)acetic acid;alpha-(4-Methoxyphenyl)phenylacetic acid
• CAS NO: 21749-83-7
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 21749-83-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 104-108°C
• Boiling Point: 389.6°C at 760 mmHg
• Flash Point: 145.4°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 9.12E-07mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-(4-METHOXYPHENYL)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYPHENYL)-2-PHENYLACETIC ACID(21749-83-7)
• EPA Substance Registry System: 2-(4-METHOXYPHENYL)-2-PHENYLACETIC ACID(21749-83-7)

Safety Data

• Hazard Codes: Xi,N,T
• Statements: 25-50
• Safety Statements: 45-61
• HazardClass: IRRITANT
• Hazardous Substances Data: 21749-83-7(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl)-2-Phenylacetic Acid is a chemical compound, usually recognized for its application in the synthesis of various pharmaceutical drugs. It contains functional groups distinctive to phenols and aromatic compounds, including a methoxy group (OCH3), which often heightens the molecule's acidity and stability. The two phenyl structures enrich the molecule with aromatic properties and contribute to its stability and reactivity. Overall, the combination of different reactive groups in its structure creates a versatile foundation for various organic reactions, making this compound particularly significant in the field of medicinal chemistry.

InChI:InChI=1/C15H14O3/c1-18-13-9-7-12(8-10-13)14(15(16)17)11-5-3-2-4-6-11/h2-10,14H,1H3,(H,16,17)

Upstream product

• 4578-79-4 2-(4-methoxyphenyl)-2-phenylacetonitrile 
• 16343-36-5 2-(4-methoxy-phenyl)-2-phenylacetaldehyde 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 103-82-2 phenylacetic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 623-12-1 4-chloromethoxybenzene 
• 124-38-9 carbon dioxide 
• 38395-64-1 4-methoxybenzophenone hydrazone 
• 104-01-8 4-Methoxyphenylacetic acid 
• 108-86-1 bromobenzene 
• 100-66-3 methoxybenzene 
• 83390-27-6 2-(4-methoxyphenyl)-2-phenyloxirane 
• 611-94-9 4-Methoxybenzophenone 
• 6731-11-9 4-methoxybenzhydryl chloride 

Downstream Products

• 101096-06-4 (4-methoxy-phenyl)-phenyl-acetyl chloride 
• 88875-64-3 2-[2-(4-Methoxy-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester 
• 129315-98-6 2-(4-methoxyphenyl)-2-phenyl-4-pentenoic acid 
• 67888-29-3 2-(4-methoxyphenyl)-2-phenylpropanoic acid 
• 88875-72-3 2-[2-(4-Methoxy-phenyl)-2-phenyl-acetoxy]-benzoic acid 
• 129315-95-3 5-(4-methoxyphenyl)-5-phenyl-2-cyclopenten-1-one 
• 129315-79-3 2-(4-hydroxyphenyl)-2-phenylcyclopentanone 
• 129315-78-2 2-(4-methoxyphenyl)-2-phenylcyclopentanone 
• 129315-89-5 trans-(1R^*,2R^*)-2-(4-hydroxyphenyl)-2-phenylcyclopentanol 
• 129315-89-5 cis-(1S^*,2R^*)-2-(4-hydroxyphenyl)-2-phenylcyclopentanol 
• 129315-87-3 trans-(1R^*,2R^*)-2-(4-methoxyphenyl)-2-phenylcyclopentanol 
• 129315-87-3 trans-(1S,2R)-2-(4-methoxyphenyl)-2-phenylcyclopentanol 
• 1061757-63-8 C₃₀H₂₉NO₂ 
• 1220911-30-7 2-(4-methoxyphenyl)-2-phenyl-N-(3-phenylpropyl)acetamide 

Relevant articles and documents

Palladium-Catalyzed ?±-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides

To date, examples of ?±-arylation of carboxylic acids remain scarce. Using a deprotonative cross-coupling process (DCCP), a method for palladium-catalyzed ?3-arylation of aryl acetic acids with aryl halides has been developed. This protocol is applicable to a wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed ?±-arylation of styryl acetic acids is also described.

Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2

The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine. Computational studies reveal that this umpolung reaction proceeds through the generation of a Ru-nitrenoid followed by concerted [4 + 2] cycloaddition with CO2.

Photostimulated reactions of phenylacetic acid dianions with aryl halides. Influence of the metallic cation on the regiochemistry of arylation.

[reaction: see text]Phenylacetic acid dianions react via what appears to be an S(RN)1 process with aryl halides under photostimulation to afford aryl substitution products 5 and 6. When the counterion is K+, only 4-biphenylacetic acids 5 are obtained. Both alpha- and para-coupling occurs with Na+ to give a mixture of 5 and 6, while exclusive formation of diphenylacetic acids 6 is observed with the dilithio salt of 1.