217494-26-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 171738-34-4 (R)-Amino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetic acid allyl ester 
• 171738-32-2 (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile 
• 171738-31-1 4-methoxy-3,5-diisopropyloxybenzaldehyde 

Downstream Products

• 178744-38-2 (R)-N-(t-butoxycarbonyl)-(3,5-diisopropyloxy-4-methoxyphenyl)glycine 

Relevant academic research and scientific papers

Asymmetric synthesis of 3,5-bis(isopropyloxy)-4-methoxyphenyl glycine by way of a diastereoselective Strecker reaction and an Evans electrophilic amination reaction

Two short syntheses of D-N-Boc-3,5-bis(isopropyloxy)-4-methoxyphenyl glycine, a central unit of vancomycin type antibiotics, have been developed. A diastereoselective Strecker reaction using (S)-phenylglycinol as a chiral inducer was the key step in the first synthesis, while Evans' electrophilic amination technology was employed for introducing both the amino function and the chirality in the second strategy.