171738-32-2

Basic information

• Product Name: (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile
• CAS NO: 171738-32-2
• Molecular Weight: 398.502
• Mol File: 171738-32-2.mol

Chemical Properties

• CAS DataBase Reference: (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile(171738-32-2)
• EPA Substance Registry System: (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile(171738-32-2)

Safety Data

• Hazardous Substances Data: 171738-32-2(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 20989-17-7 (2S)-2-phenylglycinol 
• 171738-31-1 4-methoxy-3,5-diisopropyloxybenzaldehyde 

Downstream Products

• 217494-26-3 (R)-tert-Butoxycarbonylamino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetic acid allyl ester 
• 178744-38-2 (R)-N-(t-butoxycarbonyl)-(3,5-diisopropyloxy-4-methoxyphenyl)glycine 
• 171738-35-5 (R)-(3,5-Diisopropoxy-4-methoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid allyl ester 
• 171738-34-4 (R)-Amino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetic acid allyl ester 

Relevant articles and documents

Asymmetric synthesis of 3,5-bis(isopropyloxy)-4-methoxyphenyl glycine by way of a diastereoselective Strecker reaction and an Evans electrophilic amination reaction

Two short syntheses of D-N-Boc-3,5-bis(isopropyloxy)-4-methoxyphenyl glycine, a central unit of vancomycin type antibiotics, have been developed. A diastereoselective Strecker reaction using (S)-phenylglycinol as a chiral inducer was the key step in the first synthesis, while Evans' electrophilic amination technology was employed for introducing both the amino function and the chirality in the second strategy.

Asymmetric Synthesis of (2S,3R) β-(4-F-3-NO2) phenyl Serine, D-(R)-4-methoxy-3,5-Bis tButyldimethylsiloxy Phenylglycine and Their Assemblage to C-O-D Ring of Vancomycin

The asymmetric synthesis of two appropriately functionalyzed non-proteinogenic amino acids 2 and 3 needed for the total synthesis of vancomycin was described.The assemblage of these amino acids into linear tripeptide followed by biary ether formation via intramolecular SNAr reaction led to the fully functionalized C-O-D ring vancomycin.