21756-95-6

Upstream product

• 141-43-5 ethanolamine 
• 110698-36-7 2-nitro-5-oxo-3-phenylhexanoic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 23652-90-6 (2Z)-3-amino-1-phenylbut-2-en-1-one 
• 60317-41-1 ethyl 2-(hydroxyimino)-3-oxo-3-phenylpropanoate 
• 3651-13-6 5-methyl-3-phenyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 1192718-13-0 ethyl 4-bromo-5-methyl-3-phenyl-1H-pyrrole-2-carboxylate 
• 1357024-31-7 ethyl 4-dodecanoyl-5-methyl-3-phenylpyrrole-2-carboxylate 
• 1357024-33-9 4-dodecanoyl-5-methyl-3-phenylpyrrole-2-carboxylic acid 
• 1357024-35-1 1-(2-methyl-4-phenylpyrrol-3-yl)dodecan-1-one 
• 1357024-36-2 1-(1-benzyl-2-methyl-4-phenylpyrrol-3-yl)dodecan-1-one 
• 1357024-38-4 methyl 3-(1-benzyl-4-dodecanoyl-5-methyl-3-phenylpyrrol-2-yl)propionate 
• 1357024-39-5 3-(1-benzyl-4-dodecanoyl-5-methyl-3-phenylpyrrol-2-yl)propionic acid 
• 1192718-16-3 4-bromo-5-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid 
• 1192718-14-1 ethyl 4-bromo-1,5-dimethyl-3-phenyl-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

A new and practical synthesis of pyrroles

Heating γ-nitroketones bearing an electron-withdrawing group such as an ester germinal to the nitro group with formamidinesulfinic acid and triethylamine in isopropanol produces pyrroles in good yield.

Five-membered heteroaromatic ring derivative as well as preparation method and application thereof

The invention discloses a five-membered heteroaromatic ring derivative and a preparation method and application thereof, and the compound has obvious inhibition on DHODH. The blocking effect can be used as DHODH specific inhibitor, can be used for preparing medicines for treating diseases caused by fungal infection, can be used for preparing agricultural fungicides, and has wide application prospects.

INHIBITORS OF METALLO-BETA-LACTAMASES

The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))

Synthesis and endothelin receptors binding affinity of new 1,3,5- Substituted Pyrrole-2-Carboxylic Acid Derivatives

The interest of researchers for ligands of the endothelin receptors ETA and ETB is due to their extensive therapeutic potential. In particular, receptor antagonists are useful in a number of diseases such as pulmonary hypertension, acute myocardial infarction, congestive heart failure, renal failure, and atherosclerosis. In the context of our research program aimed to the development of new endothelin receptor ligands, in this paper we describe the synthesis and structure- activity relationships of a new series of 1,3,5-substituted pyrrole-2-carboxylic acid derivatives 27-40 possessing the structural features for ET receptors binding. New synthesized compounds were tested on ETA and ETB receptors stably expressed in CHO cells and some of them showed interesting affinity and selectivity towards ETA receptors.

Rhodium Complex-Catalyzed Reaction of Isonitriles with Carbonyl Compounds: Catalytic Synthesis of Pyrroles

(Matrix Presented) Low-valent rhodium complexes are efficient catalysts for the activation of α-C-H bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding α,β-unsaturated for

THE REACTION OF β-AMINOENONES WITH α-AMINO DERIVATIVES. SYNTHESIS OF 2-FUNCTIONALIZED PYRROLES

β-Aminoenones react with ethyl glycinate, α-aminoacetonitrile and α-aminoacetamide hydrochlorides leading to 2-fuctionalized pyrroles.Although the trans-amination is a high-yield process, the transformation of the intermediate, in both basic or thermally