21758-34-9Relevant academic research and scientific papers
Synthesis, antimicrobial evaluation, and QSAR analysis of 2-isopropyl-5-methylcyclohexanol derivatives
Singh, Manjeet,Kumar, Sunil,Kumar, Ashwani,Kumar, Pradeep,Narasimhan, Balasubramanian
, p. 511 - 522 (2012/08/07)
A series of 2-isopropyl-5-methylcyclohexanol derivatives were synthesized and evaluated for their antibacterial activity against Gram-positive Staphylococcus aureus and Bacillus subtilis and Gram-negative Escherichia coli and in vitro antifungal activity against Candida albicans and Aspergillus niger. The results of antimicrobial activity demonstrated that the compounds 10, 20, and 21 were the most active ones among the synthesized compounds. The QSAR studies revealed the importance of dipole moment (μ), total energy (Te), and topological parameters (κ1 and κ3) in describing the antimicrobial activity of 2-isopropyl-5-methylcyclohexanol derivatives. Springer Science+Business Media, LLC 2011.
Dimethylmalonyltrialkylphosphoranes: Probing the steric effect on phosphorus and its stereochemical consequence in esterification reactions of chiral secondary alcohols
Dyck,Zavorine,Robertson,Capretta,Larichev,Britten,McNulty
, p. 2548 - 2552 (2007/10/03)
High chemical yields and high levels of stereochemical inversion are demonstrated in the phosphorane-mediated esterification reaction of chiral alcohols with non-hindered carboxylic acids through the incorporation of sterically non-hindered alkyl groups o
Induction of chirality by doping mesogens with non-mesogenic chiral dopant
Prajapati, Ashish K.,Patel, Niraj S.,Lad, Vijay G.
, p. 41 - 51 (2007/10/03)
Use of chiral dopant in binary mixtures to induce ferroelectricity/chiral nematic phase is an easier way than the synthesis of ferroelectric or chiral nematic materials. Number of researchers have tried to induce chirality in the achiral mesogens by doping it with naturally occurring chiral compounds or their derivatives. Few binary systems were studied where one of the components is the non-mesogenic chiral dopant. In almost all the systems studied cholesteric phase (N*) is induced with lowering in transition temperatures. The study provides means to induce chirality in mesogenic system by doping it with the derivative of naturally occurring chiral menthol.
Substituent Effect on the Enantiomer-Differentiating Reaction of Lithiomethyl p-Tolyl Sulfoxide with Meta- or Para-Substituted (R)-(-)-Menthyl Benzoates
Kunieda, Norio,Nakanishi, Takeshi,Kinoshita, Masayoshi
, p. 2229 - 2234 (2007/10/02)
Treatment of (R)-(-)-menthyl benzoates, which have a variety of meta- or para-substituents, with 2 equivalents of racemic lithiomethyl p-tolyl sulfoxide displays the feature of an enantiomer-differentiating reaction, affording the corresponding optically active β-keto sulfoxides.The degree and the direction of enantioselectivity were affected by the nature of the substituent on benzene ring.The electron-releasing substituents trend to increase the percente.e. value.The reversal in the configuration with the variation in the substituent which has a high electron-withdrawing p-CN group was also observed.The R/S values thus obtained gave a good correlation with Hammett's ? values (γ = 0.975), affording a negative straight line. based on these observations, a plausible stereochemical course of this reaction has been discussed.
