21790-17-0Relevant academic research and scientific papers
Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 2. Amides
Stout, David M.,Matier, W. L.,Barcelon-Yang, Cynthia,Reynolds, Robert D.,Brown, Barry S.
, p. 1347 - 1350 (1984)
Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the ami
Spirooxazoline Synthesis by an Oxidative Dearomatizing Cyclization
Tariq, M. Umair,Moran, Wesley J.
, p. 5153 - 5160 (2020/07/30)
Spirocyclic compounds are of increasing importance owing to their potential applications in the development of new pharmaceuticals. Herein, we describe a new, rapid access to rarely seen spirooxazolines utilizing an I(I)/I(III) reaction manifold. The scope of the cyclization using phenols and naphthols is described along with the stereoselective functionalization of the spirocycles. The application of this method to the formation of dihydrooxazines is also demonstrated.
