21797-98-8Relevant academic research and scientific papers
Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide
Ji, Fanghua,Jiang, Guangbin,Li, Xuan,Liu, Meichen,Wang, Shoucai,Zang, Jiawang
, p. 9100 - 9108 (2020)
The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is
SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR
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, (2020/11/12)
The present invention provides a structurally novel class of heterocyclic compounds of general formula I wherein L1 is heteroaryl and L2 is heteroaryl or aryl. The novel compounds are useful in a method of prevention or treatment of a condition which is m
Novel four-step method for constructing drug molecular sand pyridan with DMF and ammonium iodide as cyanation reagents
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Paragraph 0027-0028, (2019/11/21)
The invention discloses a novel four-step method for constructing drug molecular sand pyridan with DMF (N,N-dimethylformamide) and ammonium iodide as cyanation reagents. According to the novel four-step method, 2-(4-chlorophenyl) imidazole [1,2-a] pyridine is used as a reaction raw material, the DMF (N,N-dimethylformamide) and the ammonium iodide are used as the cyanation reagents, and the drug molecular sand pyridan is constructed by the four steps of a cyanation reaction, a reduction reaction, an acylation reaction and a methylation reaction. According to the novel four-step method, the synthesis method is novel, the reaction condition is mild, the reaction reagent is cheap and easy to obtain, the safe and non-toxic DMF (N,N-dimethylformamide) and the ammonium iodide are used as a combined reagent to provide acyanogen source, and the development requirements of green chemistry are conformed.
Construction of substituted 2-phenylimidazo[1,2-a]pyridine-3-nitrile by using DMF and ammonium iodide as cyanation reagents
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Paragraph 0072; 0073, (2019/12/02)
The invention discloses a novel method for one-step construction of substituted2-phenylimidazo[1,2-a]pyridine-3-nitrile by taking DMF (N,N-dimethylformamide) and ammonium iodide as cyanation reagents.According to the method, substituted 2-phenylimidazo[1,
