103844-86-6

Basic information

• Product Name: Saripidem
• Synonyms: Saripidem;Saripidem [inn];Unii-0J6174G60n
• CAS NO: 103844-86-6
• Molecular Formula: C19H20ClN3O
• Molecular Weight: 341.84
• Mol File: 103844-86-6.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.2g/cm³
• Refractive Index: 1.61
• CAS DataBase Reference: Saripidem(CAS DataBase Reference)
• NIST Chemistry Reference: Saripidem(103844-86-6)
• EPA Substance Registry System: Saripidem(103844-86-6)

Safety Data

• Hazardous Substances Data: 103844-86-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Saripidem is used as a sedative and hypnotic drug for the treatment of insomnia and other sleep disorders. It is effective in promoting sleep without causing the same level of physical dependence and tolerance associated with traditional benzodiazepine drugs.
Used in Neurology:
Saripidem is used as an anxiolytic agent for the treatment of anxiety disorders. Its anxiolytic properties make it a potential therapeutic option for individuals suffering from anxiety-related conditions.
Used in Epilepsy Treatment:
Saripidem is used as an anticonvulsant drug for the management of epilepsy. Its anticonvulsant properties suggest its potential use in controlling seizures and reducing the frequency of epileptic episodes.

InChI:InChI=1/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3

Upstream product

• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 117459-95-7 N-(prop-2-yn-1-yl)pyridin-2-amine 
• 5857-45-4 3-methylimidazo[1,2-α]pyridine 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 
• 6188-43-8 imidazo[1,2-a]pyridine-3-carbaldehyde 
• 30493-06-2 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 504-29-0 2-aminopyridine 
• 38922-74-6 2-(4-chlorophenyl)imidazolo[1,2-a]pyridine 
• 30489-48-6 (2-(4-chlorophenyl)imidazo [1,2-a] pyridin-3-yl)methanol 
• 103845-12-1 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl)methyl)butyramide 
• 74-88-4 methyl iodide 
• 141-75-3 butyryl chloride 

Relevant articles and documents

Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis

A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael ad

Cu(i)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-a]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2-a]pyridines (3e) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

Imidazo[1,2-a]pyridine-3-carboxylate derivatives and its preparation method

The present invention refers to imidazo [1, 2 a-a] pyridine - 3 - carboxylate derivatives and their manufacturing method relates to, more particularly copper (II) in the presence of α - aza - [3 + 2] die azo oxime ether derivatives and pyridine derivatives by hydrogenation of imidazo [1, 2 a-a] pyridine - 3 - carboxylate derivative ring efficiently and the imidazo [1, 2 a-a] pyridine - 3 - carboxylate prepared by the number a number bath method derivatives are disclosed. (by machine translation)

Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide

Silver-catalyzed cyclization of N-(prop-2-yn-1-yl)pyridin-2-amines

We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proce