21802-37-9 Usage
Description
Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion?in vitro?and?in vivo.1 Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling.2
Uses
Different sources of media describe the Uses of 21802-37-9 differently. You can refer to the following data:
1. Caerulomycin is a rare and unusual antibiotic containing a core 2, 2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly active against bacteria. While its discovery has stimulated some synthetic effort, little is known about the mode and spectrum of action of caerulomycin.
2. Caerulomycin A is a pyridine derived antiobiotic with a broad spectrum of bioactivity.
References
1) Singla?et al. (2014),?Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One,?9(10)?e107051
2) Gurram?et al. (2014),?Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem.?289?17515
Check Digit Verification of cas no
The CAS Registry Mumber 21802-37-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,8,0 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 21802-37:
(7*2)+(6*1)+(5*8)+(4*0)+(3*2)+(2*3)+(1*7)=79
79 % 10 = 9
So 21802-37-9 is a valid CAS Registry Number.
21802-37-9Relevant articles and documents
Facile one-pot direct arylation and alkylation of nitropyridine N -oxides with grignard reagents
Zhang, Fang,Duan, Xin-Fang
, p. 6102 - 6105 (2012/01/06)
Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred at the 3-position in an adjustably site-selective manner. The cooperative action of the two groups was discovered in the reactions of 3-nitropyridine N-oxides. This protocol can find wide applications in building various pyridine compounds as illustrated in total syntheses of Emoxipin and Caerulomycin A and E.
