21802-37-9

Basic information

• Product Name: CAERULOMYCIN A
• Synonyms: (E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime;4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime;(2,2'-Bipyridine)-6-carboxaldehyde, 4-methoxy-, oxime, (E)-;CeruloMycin, CaeruloMycin A;Carulomycin A;CAERULOMYCIN;CAERULOMYCIN A;CERULOMYCIN
• CAS NO: 21802-37-9
• Molecular Formula: C₁₂H₁₁N₃O₂
• Molecular Weight: 229.23
• Product Categories: Antibiotic
• Mol File: 21802-37-9.mol

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 400.4°Cat760mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.23g/cm³
• Storage Temp.: ?20°C
• Solubility: Soluble in DMSO (up to 10 mg/ml).
• PKA: 9.89±0.50(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• CAS DataBase Reference: CAERULOMYCIN A(CAS DataBase Reference)
• NIST Chemistry Reference: CAERULOMYCIN A(21802-37-9)
• EPA Substance Registry System: CAERULOMYCIN A(21802-37-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 21802-37-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Caerulomycin A is used as an immunosuppressive agent for its ability to suppress T cell activation and IFNγ secretion. This property makes it a valuable compound in the development of treatments for autoimmune diseases and conditions requiring immune modulation.
Used in Antifungal Applications:
Caerulomycin A is used as an antifungal agent due to its activity against fungi. This application can be beneficial in the development of treatments for various fungal infections.
Used in Antiprotozoan Applications:
Caerulomycin A is also used as an antiprotozoan agent, as it demonstrates activity against some protozoans. This can be useful in the treatment of protozoan infections, such as those caused by parasites.
Used in Antibacterial Applications:
Although its activity against bacteria is weak, Caerulomycin A can still be used as a weak antibacterial agent. This may be beneficial in certain situations where a broad-spectrum approach to treatment is necessary.
Used in Research and Development:
Caerulomycin A's unique chemical structure and broad spectrum of bioactivity make it an interesting compound for research and development in the pharmaceutical and biotechnology industries. It can be used as a starting point for the development of new drugs and therapies targeting various diseases and conditions.

References

1) Singla?et al. (2014),?Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One,?9(10)?e107051 2) Gurram?et al. (2014),?Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem.?289?17515

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 

Downstream Products

• 98-98-6 2-Picolinic acid 

Relevant articles and documents

Facile one-pot direct arylation and alkylation of nitropyridine N -oxides with grignard reagents

Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred at the 3-position in an adjustably site-selective manner. The cooperative action of the two groups was discovered in the reactions of 3-nitropyridine N-oxides. This protocol can find wide applications in building various pyridine compounds as illustrated in total syntheses of Emoxipin and Caerulomycin A and E.