21816-42-2

Basic information

• Product Name: 2,5-Dimethyl-4-nitropyridine 1-oxide
• Synonyms: 2,5-Dimethyl-4-nitropyridine 1-oxide;2,5-diMethyl-4-nitropyridine;Pyridine,2,5-dimethyl-4-nitro-, 1-oxide
• CAS NO: 21816-42-2
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.17
• Mol File: 21816-42-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 297.07°C (rough estimate)
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.3722 (rough estimate)
• Vapor Pressure: 4.72E-06mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• CAS DataBase Reference: 2,5-Dimethyl-4-nitropyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethyl-4-nitropyridine 1-oxide(21816-42-2)
• EPA Substance Registry System: 2,5-Dimethyl-4-nitropyridine 1-oxide(21816-42-2)

Safety Data

• Hazardous Substances Data: 21816-42-2(Hazardous Substances Data)

Usage

General Description

2,5-Dimethyl-4-nitropyridine 1-oxide is a chemical compound with the molecular formula C7H8N2O3. It is a yellow crystalline solid and is often used as a radical initiator in polymerization reactions. 2,5-Dimethyl-4-nitropyridine 1-oxide is also known for its application as a reagent in organic synthesis, particularly for the oxidation of alcohols to carbonyl compounds. Additionally, 2,5-Dimethyl-4-nitropyridine 1-oxide has been studied for its potential biological activities, including its role in inhibiting the growth of various cancer cell lines. It is important to handle this compound with care, as it can be harmful if ingested or inhaled, and it may cause skin and eye irritation.

InChI:InChI=1/C7H8N2O3/c1-5-4-8(10)6(2)3-7(5)9(11)12/h3-4H,1-2H3

Upstream product

• 4986-05-4 2,5-dimethylpyridine N-oxide 
• 589-93-5 2,5-dimethylpyridine 
• 7664-93-9 sulfuric acid 

Downstream Products

• 1196157-14-8 4-bromo-5-methylpyridine-2-carbaldehyde 
• 820224-83-7 (4-bromo-5-methylpyridin-2-yl)methanol 
• 103577-41-9 2-[5-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethylsulfanyl]-1H-benzoimidazole 
• 94452-59-2 2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride 
• 94452-65-0 2-hydroxymethyl-4-methoxy-5-methylpyridine 
• 155919-05-4 1,4-dihydro-5-methyl-3-nitro-4-oxo-2-pyridinecarboxylic acid 
• 155919-10-1 2,5-dimethyl-4-methoxypyridine 
• 193690-65-2 1,4,7-Trimethyl-1H-imidazo[4,5-c]pyridin-2-ylamine 
• 193690-64-1 3-amino-2,5-dimethyl-4-methylaminopyridine 
• 193690-61-8 2,5-dimethyl-4-methylaminopyridine 
• 22279-89-6 4-amino-2,5-dimethylpyridine 

Relevant articles and documents

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B

A structure-activity relationship investigation of various 6-(azaindol-2-yl)pyridine-3-sulfonamides using the HCV replicon cell culture assay led to the identification of a potent series of 7-azaindoles that target the hepatitis C virus NS4B. Compound 2ac, identified via further optimization of the series, has excellent potency against the HCV 1b replicon with an EC50 of 2 nM and a selectivity index of >5000 with respect to cellular GAPDH RNA. Compound 2ac also has excellent oral plasma exposure levels in rats, dogs and monkeys and has a favorable liver to plasma distribution profile in rats.

Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that incorporate a 7-indolizinylamino or 2-naphthylamino substituent on a pyrimidine or 1,3,5-triazine core. The most potent compounds show below 10 nanomolar activity towards wild-type HIV-1 and variants bearing Tyr181Cys and Lys103Asn/Tyr181Cys resistance mutations. The compounds also feature good aqueous solubility. Crystal structures for two complexes enhance the analysis of the structure-activity data.

Syntheses of five potential heterocyclic amine food mutagens

The syntheses of the potential heterocyclic amine food mutagens, 3,5,7- trimethyl-2-aminoimidazo[4,5-b]pyridine, 1,4,7-trimethyl-2-aminoimidazo[4,5- c]pyridine, 1,6,7-trimethyl-2-aminoimidazo[4,5-c]-pyridine, 3,4,6-trimethyl- 2-aminoimidazo[4,5-c]pyridine, and 1,4,6-trimethyl-7-aminoimidazo[4,5-c]- pyridine are described.