218301-87-2

Basic information

• Product Name: 4-N-Boc-amino-3-fluorophenylboronic acid
• Synonyms: 4-(tert-butoxycarbonyl)-3-fluorophenylboronic acid;4-N-Boc-amino-3-fluorophenylboronic acid;tert-butyl N-{[(3-fluorophenyl)(hydroxy)boranyl]oxy}carbaMate;4-N-BOC-AMINO-3-FLUOROPHENYLBO;(4-{[(tert-Butoxy)carbonyl]amino}-3-fluorophenyl)boronic acid
• CAS NO: 218301-87-2
• Molecular Formula: C₁₁H₁₅BFNO₄
• Molecular Weight: 255.05
• Mol File: 218301-87-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.244 g/cm³
• Refractive Index: 1.517
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 4-N-Boc-amino-3-fluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-Boc-amino-3-fluorophenylboronic acid(218301-87-2)
• EPA Substance Registry System: 4-N-Boc-amino-3-fluorophenylboronic acid(218301-87-2)

Safety Data

• Hazardous Substances Data: 218301-87-2(Hazardous Substances Data)

Usage

General Description

4-N-Boc-amino-3-fluorophenylboronic acid is a chemical compound that belongs to the class of boronic acids. It contains a boron atom attached to a phenyl ring with a fluorine atom at the 3-position and an amino group protected by a Boc (tert-butyloxycarbonyl) group at the 4-position. 4-N-Boc-amino-3-fluorophenylboronic acid has been widely used as a building block in the synthesis of pharmaceuticals and agrochemicals, as well as in the development of new materials and catalysts. It is known for its ability to form stable complexes with diols and has found applications in the selective functionalization of biomolecules and the construction of organic frameworks. Additionally, the presence of the Boc protecting group enables the compound to undergo various chemical transformations while maintaining its stability and reactivity.

InChI:InChI=1/C11H15BFNO4/c1-11(2,3)18-10(15)14-9-5-4-7(12(16)17)6-8(9)13/h4-6,16-17H,1-3H3,(H,14,15)

Upstream product

• 367-24-8 4-bromo-2-fluoroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 209958-42-9 tert-butyl N-(4-bromo-2-fluorophenyl)carbamate 
• 121-43-7 Trimethyl borate 

Downstream Products

• 218301-88-3 2-Fluoro-4-(2-methyl-imidazol-1-yl)-phenylamine 
• 1075189-04-6 tert-butyl 4-(2-(1-ethyl-4-hydroxypiperidin-4-yl)thiazol-5-yl)-2-fluorophenylcarbamate 
• 1233692-95-9 tert-butyl 3-fluoro-4'-[2-methyl-1-(pyridin-4-yl)prop-1-enyl]biphenyl-4-ylcarbamate 
• 819058-34-9 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1374109-76-8 C₂₂H₂₄FN₃O₂ 
• 1374107-85-3 2-(4-amino-3-fluorophenyl)-6-dimethylaminoquinoline 
• 1374109-75-7 C₂₂H₂₂FN₃O₃ 
• 1448987-73-2 [4-(6-ethyl-8,8-dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl)-2-fluorophenyl]carbamic acid tert-butyl ester 
• 1276129-51-1 tert-butyl {4-[1-(4-chlorobenzyl)-4-oxo-1,4-dihydrothieno[3,2-d]pyrimidin-6-yl]-2-fluorophenyl}carbamate 
• 1276129-75-9 N-{4-[1-(4-chloro-benzyl)-4-oxo-1,4-dihydro-thieno[3,2-d]pyrimidin-6-yl]-2-fluoro-phenyl}-benzamide 
• 1093628-98-8 O-[tert-Butyl] N-[2-fluoro-4-(1-methyl-2-oxo-1,2-dihydropyridin-3-yl)phenyl]carbamate 
• 912954-82-6 1,1-dimethylethyl [4-(2,2-difluoro-1,3-benzodioxol-5-yl)-2-fluorophenyl]carbamate 
• 262444-42-8 tert-butyl N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 

Relevant articles and documents

Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same

The invention relates to substituted sulphoximines according to the general formula (I): in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8, m, p, q, are given in the

NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.