218444-76-9Relevant academic research and scientific papers
Design and synthesis of a pyridone-based phosphotyrosine mimetic
Fu, Jian-Min,Castelhano, Arlindo L.
, p. 2813 - 2816 (2007/10/03)
A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β- iodoalanine with phosphonomethyl 4-pyridone triflate.
Synthesis of functionalized pyridones via palladium catalyzed cross coupling reactions
Fu, Jian-Min,Chen, Yong,Castelhano, Arlindo L.
, p. 1408 - 1410 (2007/10/03)
Convenient, palladium catalyzed cross coupling reaction conditions lead to novel N- and 4-substituted pyridones.
