21847-96-1

Upstream product

• 1539-32-8 4-isopropyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 22422-22-6 3-chloro-1-(2,4-dimethylphenyl)propan-1-one 
• 38136-29-7 4-methylvaleroyl chloride 
• 108-38-3 m-xylene 
• 3123-97-5 dihydro-5,5-dimethyl-2(3H)-furanone 
• 106-42-3 para-xylene 

Relevant academic research and scientific papers

Mn-Enabled Radical-Based Alkyl-Alkyl Cross-Coupling Reaction from 4-Alkyl-1,4-dihydropyridines

Highly efficient alkylation of β-chloro ketones and their derivatives was achieved by means of domino dehydrochlorination/Mn-enabled radical-based alkyl-alkyl cross-coupling reaction. In situ-generated α,β-unsaturated ketones and their analogues were identified as the reaction intermediates. Known bioactive compounds, such as melperone and azaperone, could be easily prepared from β-chloropropiophenone in two steps.

Hydride Transfers During Friedel-Crafts Reactions of 5,5-Dimethyl-4,5-dihydrofuran-2(3H)-one

5,5-Dimethyl-4,5-dihydrofuran-2(3H)-one (4,4-dimethylbutyrolactone) reacts with toluene and with p-xylene in the presence of anhydrous aluminium chloride to give 4-methylpentanoyl benzenes with one, two or three methyls on the benzene ring.Reduction of the side chain has taken place by hydride transfer from an aromatic methyl, the resulting benzylic carbocation going on to form diarylmethanes by reaction with solvent molecules.