21849-91-2

Usage

Uses

Used in Pharmaceutical Synthesis:
[1,1'-Biphenyl]-2-ol, 4'-methoxyis used as an intermediate in the synthesis of pharmaceuticals for its ability to introduce the methoxy group into other organic molecules, which can enhance the properties and efficacy of the final product.
Used in Agrochemical Synthesis:
In the agrochemical industry, [1,1'-Biphenyl]-2-ol, 4'-methoxyis utilized as a building block for the development of new agrochemicals, such as pesticides and herbicides, due to its potential to improve the performance and selectivity of these compounds.
Used in Organic Material Synthesis:
[1,1'-Biphenyl]-2-ol, 4'-methoxyis employed in the synthesis of various organic materials, where its unique structure and functional groups contribute to the development of novel materials with improved properties.
Used as a Reagent in Organic Chemistry:
[1,1'-Biphenyl]-2-ol, 4'-methoxyis used as a reagent in organic chemistry reactions, particularly for the introduction of the methoxy group into other organic molecules. This can lead to the creation of new compounds with enhanced properties and potential applications in various industries.
Used in Antioxidant and Anti-Inflammatory Applications:
Due to its potential antioxidant and anti-inflammatory properties, [1,1'-Biphenyl]-2-ol, 4'-methoxyis being studied for its use in the development of new therapeutic agents and treatments for various conditions, including inflammation and oxidative stress-related diseases.

Upstream product

• 65109-75-3 N-(phenoxy)-4-methylbenzenesulfonamide 
• 100-66-3 methoxybenzene 

Downstream Products

• 42523-32-0 8-methoxy-6H-dibenzo[b,d]pyran-6-one 

Relevant academic research and scientific papers

Acid-Catalyzed Solvolysis of N-Sulfonyl- and N-Acyl-O-arylhydroxylamines. Phenoxenium Ions

The acid-catalyzed reaction of N-acyl- and N-sulfonyl-O-arylhydroxylamines with benzene proceeded quite smoothly to give 2- and 4-hydroxybiphenyls.The results of product analysis, the orientation of the reaction, and the effects of substituents on the nitrogen atom and on the phenyl ring suggested a mechanism that involves a phenoxenium ion.The phenoxenium ion was trapped by benzene and other various nucleophiles.

PHENOXENIUM IONS. IDENTICAL INTERMEDIATES IN THE ACID-CATALYZED SOLVOLYSIS OF N-TOSYL-O-ARYLHYDROXYLAMINES AND IN THE THERMOLYSIS OF N-ARYLOXYPYRIDINIUM SALTS

The acid-catalyzed solvolysis of N-tosyl-O-arylhydroxylamines in aromatic solvents and the thermolysis of N-aryloxypyridinium salts involve common intermediates, phenoxenium ions, for the formation of hydroxybiphenyl derivatives.Diphenylethers are formed when the heterolysis of the N-O bonds is slow and the aromatic solvent has high nucleophilicity.

Aryloxenium Ions. Generation from N-(Aryloxy)pyridinium Tetrafluoroborates and Reaction with Anisole and Benzonitrile

N-(Aryloxy)pyridinium tetrafluoroborates (4) decompose thermally at 180-200 deg C in anisole and benzonitrile to form products of intermolecular C-O-C and C-C bond formation.With anisole, diphenyl ethers (5) and hydroxybiphenyls (6) are formed; with benzonitrile, the main product is benzoxazole (14).A homolytic process was ruled out by showing that none of these products were formed when perbenzoyl p-nitrophenyl carbonate (18) was decomposed in these solvents.The main products in this case were those of homolytic phenylation (and benzoyloxylation with anisole).A concerted SN2-type heterolytic process was ruled out by showing that the nature of the substituent in the pyridine ring had no effect on the isomer ratios of 5 and 6 in the thermolysis of 4 (X = p-NO2) in anisole.The results are explained in terms of a unimolecular heterolysis of 4 to give the pyridine and aryloxenium ion 2 which now attacks solvent molecules.When an electron-withdrawing substituent is present in 2, more C-O-C than C-C products are formed in anisole.When it is absent only products of C-C bond formation are found.PhO+ is apparently electrophilic enough to attack anisole and give the four possible hydroxymethoxybiphenyls (10-13).