65109-75-3

Upstream product

• 4846-21-3 O-phenylhydroxylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 6092-80-4 phenoxyamine hydrochloride 
• 98-80-6 phenylboronic acid 
• 64908-64-1 2-phenoxyisoindol-1,3-dione 

Downstream Products

• 65109-81-1 2-hydroxyphenyl p-toluenesulfonimidate 
• 150-76-5 4-methoxy-phenol 
• 90-05-1 2-methoxy-phenol 
• 129560-99-2 4-(2,2,2-trifluoroethoxy)phenol 
• 65109-80-0 4-hydroxyphenyl trifluoromethanesulfonate 
• 160968-99-0 2-O-(2,2,2-trifluoroethyl)catechol 
• 2848-25-1 2-acetoxyphenol 
• 3233-32-7 hydroquinone monoacetate 
• 21849-91-2 2-(4-methoxyphenyl)phenol 
• 3594-88-5 2-(2-methoxyphenyl)phenol 
• 16881-71-3 4'-methoxy-1,1'-biphenyl-4-ol 
• 65109-82-2 2'-methoxy-1,1'-biphenyl-4-ol 
• 103-90-2 4-acetaminophenol 
• 29549-60-8 2-(ethylthio)phenol 

Relevant academic research and scientific papers

Hexafluoroisopropanol (HFIP)-prompted rearrangement of N-phenoxysulfonamides for the direct assembly of ortho-sulfonamide phenols: A combined experimental and computational study

ortho-Sulfonamide phenols represent a class of attractive structural motifs in medicinal and synthetic chemistry. Herein an efficient metal-free rearrangement reaction has been developed for the construction of ortho-sulfonamide phenols via HFIP-prompted

Rhodium(III)-Catalyzed Enantio- and Diastereoselective C?H Cyclopropylation of N-Phenoxylsulfonamides: Combined Experimental and Computational Studies

Cyclopropane rings are a prominent structural motif in biologically active molecules. Enantio- and diastereoselective construction of cyclopropanes through C?H activation of arenes and coupling with readily available cyclopropenes is highly appealing but

Rhodium(III)-catalyzed redox-neutral coupling of N-phenoxyacetamides and alkynes with tunable selectivity

Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed C-H functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp=C5Me5). Copyright

Rhodium(III)-catalyzed C-H olefination for the Synthesis of ortho-alkenyl phenols using an oxidizing directing group

By using an oxidizing directing group, a mild, efficient Rh(III) catalyzed C-H olefination reaction between N-phenoxyacetamides and alkenes was developed. This reaction provided a straightforward way for the synthesis of ortho-alkenyl phenols, and the directing group is traceless in the product.

O-Substituted N-oxy arylsulfinamides and sulfonamides in Michael reactions

O-Substituted N-oxy arylsulfinamides and sulfonamides undergo fast aza-Michael reaction in the presence of base and electron-deficient α,β-unsaturated olefins under mild conditions. With N-silyloxy benzenesulfinamides, no aza-Michael product is observed and a hetero aza-Brook type rearrangement takes place induced by the base. Room temperature N-desulfinylation of N-benzyloxybenzenesulfinamide is achieved using BF 3.Et2O. N-Alkoxy arylsulfonamides aza-Michael adducts are found to be generally highly stable under strongly acidic and basic conditions.

Acid-Catalyzed Solvolysis of N-Sulfonyl- and N-Acyl-O-arylhydroxylamines. Phenoxenium Ions

The acid-catalyzed reaction of N-acyl- and N-sulfonyl-O-arylhydroxylamines with benzene proceeded quite smoothly to give 2- and 4-hydroxybiphenyls.The results of product analysis, the orientation of the reaction, and the effects of substituents on the nitrogen atom and on the phenyl ring suggested a mechanism that involves a phenoxenium ion.The phenoxenium ion was trapped by benzene and other various nucleophiles.