218601-17-3Relevant academic research and scientific papers
Synthesis and antiviral activity of novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines
Kim, Hea Ok,Kim, Yun Ha,Suh, Hwal,Jeong, Lak Shin
, p. 599 - 603 (2007/10/03)
Novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-β-N6-methyladenine (ent-22a) and D-α-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity.
Synthesis and antiviral activity of D- and L-2′-azido-2′,3′-dideoxy-4′-thiopyrimidine and purine nucleosides
Jeong,Kim,Kim,Yoo,Park,Yeon,Chun,Kim
, p. 665 - 668 (2007/10/03)
Novel D- and L-2′-azido-2′,3′-dideoxy-4′-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 μg/ml.
Participation of sulfur occurred during the Mitsunobu reaction: Synthesis of novel isodideoxythionucleosides
Jeong, Lak Shin,Yoo, Su Jeong,Moon, Hyung Ryong,Kim, Yun Ha,Chun, Moon Woo
, p. 3325 - 3326 (2007/10/03)
Novel isodideoxythionucleosides have been synthesized from our versatile intermediate, L-4-thioarabitol derivative 5 using the Mitsunobu reaction as a key step. It is found that the sulfur atom of the 4-thiofuranose derivative takes part in the Mitsunobu
