21863-63-8Relevant academic research and scientific papers
Application of O-sulfonic acid poly(4-vinylpyrrolidonium) chloride as an efficient polymer-supported catalyst in the rapid synthesis of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products
Dalil Heirati, Seyedeh Zahra,Shirini, Farhad,Fallah Shojaei, Abdollah
, p. 3217 - 3225 (2020/07/02)
In this work, a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products were efficiently synthesized for the first time using O-Sulfonic acid poly(4-vinylpyrrolidonium) chloride ([PVP-SO3H]Cl) as an eco-friendly polymer-supp
PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions
Dalil Heirati, Seyedeh Zahra,Shirini, Farhad,Shojaei, Abdollah Fallah
, p. 67072 - 67085 (2016/07/30)
A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting
A regioselective biginelli-like reaction controlled by the size of alicyclic mono-ketones
Wan, Yu,Yuan, Rui,Xu, Hua-Hong,Wang, Chao,Qi, Jin-Long,Wu, Hui
, p. E123-E128 (2014/10/16)
A regioselective Biginelli-like reaction of alicyclic mono-ketones, aromatic aldehydes, and urea in ionic liquid [BPY]BF4 has been investigated. The process is controlled by the size of alicyclic mono-ketones and the steric hindrance of aromatic aldehydes. The reaction of cyclopentanone with urea and aromatic aldehydes afforded 7-arylidene-3,4,6,7-tetrahydro-4-aryl- 1H-cyclopenta[d]pyrimidin-2(5H)-ones (4). When cyclohexanone was used as the source of active methylene to react with urea and aldehydes with slight steric hindrance groups under the same condition, 8-arylidene-3,4,5,6,7, 8-hexahydro-4-arylquinazolin-2(1H)-ones (6), a homologue of 4, were yielded, whereas 4,8-bisaryloc-tahydro-1H-pyrimido[5,4-i]-quinazoline-2,10(3H,11H)-diones (7) were obtained via the simple one-pot reaction of cyclohexanone, urea, and aromatic aldehydes with high steric hindrance groups. The possible transitional states and mechanism of the regioselective process were discussed.
An efficient and environmentally friendly procedure for the synthesis of some novel 8-Benzylidene-4-phenyl-3,4,5,6,7,8-hexahydro-1H-quinazolin-2-ones/ thiones using tetrabutylammonium hexatungstate as a reusable heterogeneous catalyst under solvent-free conditions
Ghashang, Majid,Mansoor, Syed Sheik,Aswin, Krishnamoorthy
, p. 3289 - 3294 (2014/01/06)
An efficient method for the preparation of 8-benzylidene-4-phenyl-3,4,5,6, 7,8-hexahydro-1H-quinazolin-2- ones/thiones from the reaction of aromatic aldehydes with cyclohexanone and urea or thiourea in the presence of Tetrabutylammonium hexatungstate, [TBA]2[W6O 19], as an efficient, inexpensive catalyst under thermal and solvent-free conditions has been developed. Good yields, short reaction times, straightforward workup, reusability of the catalyst, and green conditions are the most obvious advantages of this procedure.
REACTIONS OF MONO- AND DIARYLIDENECYCLOALKANONES WITH THIOUREA AND AMMONIUM THIOCYANATE, III. ACYLATION AND ALKYLATION OF 3,4,5,6,7,8-HEXAHYDRO-2(1H)-QUINAZOLINETHIONES
Lorand, T.,Szabo, D.,Foeldesi, A.
, p. 147 - 160 (2007/10/02)
4-Phenyl-3,4,5,6,7,8-hexahydro-2(1H)-quinazolinone(B), -quinazolinethione (A) and their 8-benzylidene derivatives (C,D) were acylated in position 3.With alkyl halides A and C gave 2-alkylmercapto derivatives (Vc, VIa-Xa).The tautomerism of VIb-IXb is disc
