21864-88-0Relevant academic research and scientific papers
RuO4-mediated oxidation of secondary amines. Part 1. Are hydroxylamines the main intermediates?
Florea, Cristina A.,Petride, Horia
, p. 475 - 486 (2016/07/20)
The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a and b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a and b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detect
On the Preparation of Acyl Cyanides from Aldehydes
Haerle, Helmut,Jochims, Johannes C.
, p. 1400 - 1412 (2007/10/02)
The O-silylated cyanohydrins 3 prepared from the aldehydes 1 with trimethylsilyl cyanide are oxidized photochemically or thermally with N-bromosuccinimide to afford the acyl cyanides 4a-n.Scope and limitations of the procedure are discussed.
Cyano-O-silylhydroxylamines as Nitrone Blocking Groups
Padwa, Albert,Koehler, Konrad F.
, p. 789 - 790 (2007/10/02)
Addition of trimethylsilyl cyanide to N-alkyl-C-phenylnitrones affords cyano-O-silylhydroxylamines; reaction of these species with silver fluoride regenerates the nitrone in quantitative yield thereby providing a useful nitrone blocking group.
The Reaction between Cyanide Ion and Nitrones; a Novel Imidazole Synthesis
Cawkill, Eric,Clark, Nigel G.
, p. 244 - 248 (2007/10/02)
By contrast with the CN-diphenylnitrones, cold aqueous ethanolic potassium cyanide converts N-methyl-C-phenylnitrone into 1-methyl-4,5-diphenylimidazole.The scope of this reaction has been investigated, and shown to proceed via intermediate cyano-imines, some of which have been synthesised by alternative routes.
