21869-36-3Relevant academic research and scientific papers
Efficient Removal of N-Benzyloxycarbonyl Group by a 'Push-Pull' Mechanism using Thioanisole-Trifluoroacetic Acid, Examplified by a Synthesis of Met-Enkephalin
Kiso, Yoshiaki,Ukawa, Kazuko,Akita, Tadashi
, p. 101 - 102 (2007/10/02)
The N-benzyloxycarbonyl group can be smoothly cleaved under mild conditions, using thioanisole-trifluoroacetic acid, which can deprotect O-benzyltyrosine without the formation of O-to-C rearrangement products; this deblocking method was successfully applied to the synthesis of Met-enkephalin.
