21871-49-8Relevant academic research and scientific papers
One-pot synthesis of 5-alkylsulfanyl-1H-tetrazoles from alkyl halides
Myznikov,Vorona,Artamonova,Zevatskii, Yu. E.
, p. 1313 - 1316 (2017/08/08)
An efficient one-pot method for the synthesis of 5-alkylsulfanyl-1H-tetrazoles, tetrazol-5-ylmethane- and -ethanethiol derivatives was developed.
Synthesis of thiotetrazoles and arylaminotetrazoles using rutile TiO 2 nanoparticles as a heterogeneous and reusable catalyst
Maham, Mehdi,Khalaj, Mehdi
, p. 502 - 506 (2014/11/08)
A novel method is described to prepare rutile TiO2 nanoparticles which are reusable and efficient heterogeneous catalysts for the synthesis of thiotetrazoles and arylaminotetrazoles - compounds widely used in medicinal and coordination chemistry. This procedure has the advantages of good to excellent yields of products, elimination of homogeneous catalysts and toxic and explosive reagents, simple methodology, easy work up and the reusability of the heterogeneous catalyst.
Preparation of 5-alkylthio and 5-arylthiotetrazoles from thiocyanates using phase transfer catalysis
LeBlanc, Blaise W.,Jursic, Branko S.
, p. 3591 - 3599 (2007/10/03)
A very efficient method of preparation for 5-alkyl and 5- arylthiotetrazoles from the corresponding alkyl or aryl halides is described. The halides are first transformed into thiocyanates which further react with azide, yielding the corresponding tetrazoles with [2+3] polar cycloaddition. All synthetic transformations are performed under phase transfer catalytic conditions. The yields vary from good to excellent except for the preparation of 5-benzylthiotetrazole, where the reaction between benzyl thiocyanate and azide [2+3] cycloaddition is in competition with nucleophilic substitution, with benzyl azide as product.
