Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2189-83-5

Post Buying Request

2189-83-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2189-83-5 Usage

General Description

(4beta,5beta,17beta)-17-hydroxy-4,5-epoxyandrostan-3-one is a steroid compound with a hydroxy group at carbon 17, an epoxy group at carbons 4 and 5, and a ketone functional group at carbon 3. It is a synthetic derivative of testosterone and exhibits potent androgenic effects. (4beta,5beta,17beta)-17-hydroxy-4,5-epoxyandrostan-3-one is commonly used in the development of anabolic steroids and has been studied for its potential medical applications, including as a treatment for hormone-related conditions such as hypogonadism and androgen deficiency. Additionally, it has been investigated for its potential use as a performance-enhancing drug in athletics. Overall, (4beta,5beta,17beta)-17-hydroxy-4,5-epoxyandrostan-3-one is an important chemical compound with diverse biological and pharmaceutical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 2189-83-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,8 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2189-83:
(6*2)+(5*1)+(4*8)+(3*9)+(2*8)+(1*3)=95
95 % 10 = 5
So 2189-83-5 is a valid CAS Registry Number.

2189-83-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 17|A-Hydroxy-5-oxo-A-nor-3,5-secoandrostan-3-oic Acid

1.2 Other means of identification

Product number -
Other names (3S,3aS,5aS,6R,9aS,9bS)-Dodecahydro-3-hydroxy-3a,6-dimethyl-7-oxo-1H-benz[e]indene-6-propanoic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2189-83-5 SDS

2189-83-5Relevant articles and documents

A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone

Kiebist, Jan,Schmidtke, Kai-Uwe,Zimmermann, J?rg,Kellner, Harald,Jehmlich, Nico,Ullrich, René,Z?nder, Daniel,Hofrichter, Martin,Scheibner, Katrin

, p. 563 - 569 (2017)

Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less-activated hydrocarbons, by transferring peroxide-borne oxygen. We investigated a cell-free approach to incorporate epoxy and hydroxyl functionalities directly into the bulky molecule testosterone by a novel unspecific peroxygenase (UPO) that is produced by the ascomycetous fungus Chaetomium globosum in a complex medium rich in carbon and nitrogen. Purification by fast protein liquid chromatography revealed two enzyme fractions with the same molecular mass (36 kDa) and with specific activity of 4.4 to 12 U mg?1. Although the well-known UPOs of Agrocybe aegerita (AaeUPO) and Marasmius rotula (MroUPO) failed to convert testosterone in a comparative study, the UPO of C. globosum (CglUPO) accepted testosterone as substrate and converted it with total turnover number (TTN) of up to 7000 into two oxygenated products: the 4,5-epoxide of testosterone in β-configuration and 16α-hydroxytestosterone. The reaction performed on a 100 mg scale resulted in the formation of about 90 % of the epoxide and 10 % of the hydroxylation product, both of which could be isolated with purities above 96 %. Thus, CglUPO is a promising biocatalyst for the oxyfunctionalization of bulky steroids and it will be a useful tool for the synthesis of pharmaceutically relevant steroidal molecules.

Unambiguous assignment of 13C NMR signals in epimeric 4,5-epoxy-3-oxo-steroids assisted by X-ray diffraction and Gauge Invariant Atomic Orbitals calculation of absolute isotropic shieldings

Labra-Vazquez, Pablo,Galano, Annia,Romero-Avila, Margarita,Flores-Alamo, Marcos,Iglesias-Arteaga, Martin A.

, p. 107 - 125 (2013/09/12)

Complete assignments of the 13C signals of diastereomeric 4,5-epoxy-3-oxo steroids based on a combination of 1D and 2D NMR techniques are described The assignments were corroborated or corrected by calculation of the absolute isotropic 13C NMR shieldings using the Gauge Invariant Atomic Orbitals (GIAO) method at B3LYP/6-31+G(d,p) level. ARKAT-USA, Inc.

Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate

Carvalho, Jo?o F.S.,Silva, M. Manuel Cruz,Sá e Melo, M. Luisa

experimental part, p. 2773 - 2781 (2009/08/15)

Fast generation of epoxides from the corresponding homoallylic and allylic steroidal olefins was developed by using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) as oxidant suspended in acetonitrile (CH3CN) at reflux temperature. The protocol involves the use of a safe readily available oxidant along with an easy work-up, which renders the process very efficient. Selective 4,5- and 5,6-epoxidations of steroids are reported. Among them, highly stereoselective epoxidation of Δ5-B-nor-cholestanes was achieved. Moreover, the method is chemoselective for the 5,6-position and can be applied to the epoxidation of ring-A enones.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2189-83-5