218941-38-9Relevant academic research and scientific papers
Design and synthesis of new curcuminoid compounds and their derivatives as antioxidant agents
Abood, Rehab G.,Alsalim, Tahseen A.,Abood, Einas A.
, p. 2173 - 2183 (2021/04/22)
A series of new curcumin analogues and their derivatives were synthesized by reacting curcumin analogues with various substituted hydrazine compounds to afford new pyrazol derivatives. The preparation of ether and ester derivatives was also carried out. All synthesized compounds were characterized using FT-IR, 1HNMR, 13CNMR, and MS-ESI. The evaluations of these compounds have shown a good inhibition activity as antioxidant agents against the stable radical of diphenylpicrylhydrazyl (DPPH). Findings from this work demonstrated a high inhibition activity in compounds substituted with hydroxyl phenol groups in comparison with compounds with other groups.
Aerobic, Cu-catalyzed desulfitative C-C bond-forming reaction of ketene dithioacetals/vinylogous thioesters and arylboronic acids
Dong, Ying,Wang, Mang,Liu, Jun,Ma, Wei,Liu, Qun
supporting information; experimental part, p. 7380 - 7382 (2011/08/05)
A new Cu-catalyzed thioorganic-boronic acid desulfitative C-C bond-forming reaction involving ketene dithioacetals/ vinylogous thioesters is reported to proceed without the assistance of ligating S-pendant. Vinylogous thiolesters and tetrasubstituted olefins were prepared by this reaction in which Cu catalyst plays a dual role under aerobic conditions.
Synthesis of functionalized allylic sulfoxides and their use in the construction of 2,3,4-trisubstituted furans via a [3 + 2] annulation
Fu, Zhenqian,Wang, Mang,Ma, Yuhui,Liu, Qun,Liu, Jun
, p. 7625 - 7630 (2008/12/22)
(Chemical Equation Presented) A route to 2,3,4-trisubstituted furan derivatives based on a [3 + 2] annulation of functionalized allylic sulfoxides and aldehydes is described. In this strategy, the precursors of allylic sulfoxides 4, allylic sulfides 3, were synthesized via a thiomethylation reaction of an α-EWG ketene-S,S-acetal 1 (EWG: electron-withdrawing group), formaldehyde, and a thiol 2 in high to excellent yields. Allylic sulfoxides 4 were prepared by a highly regioselective oxidation of 3, using m-chloroperoxybenzoic acid as oxidant. Thus, starting from these readily available sulfoxides 4, 2-alkylthio-3,4-disubstituted furans 6 were efficiently constructed via the [3 + 2] annulation reaction of 4 with aldehydes 5 under mild conditions. Further replacement of the 2-alkylthio group of 6 with amines led to the formation of 2-amino-3,4-disubstituted furan derivatives 7.
A clean, facile and practical synthesis of α-oxoketene S,S-acetals in water
Ouyang, Yan,Dong, Dewen,Yu, Haifeng,Liang, Yongjiu,Liu, Qun
, p. 206 - 210 (2007/10/03)
A clean, facile and practical synthesis of α-oxoketene S,S-acetals in water has been developed. Catalyzed by tetrabutylammonium bromide (TBAB) at room temperature in water, a range of β-dicarbonyl compounds have been converted to the corresponding α-oxoke
Application of commercially available anhydrous potassium fluoride for a convenient synthesis of ketene dithioacetals
Mashraqui, Sabir H.,Hariharasubrahmanian, Harini
, p. 492 - 493 (2007/10/03)
Commercially available anhydrous KF without activation or solid support promotes condensation between active methylene compounds, carbon disulfide and an alkylating agent in dry DMF to allow the preparation of a variety of ketene dithioacetals in fair to good yields under ambient conditions.
