19434-35-6

Usage

Uses

Used in Fragrance Industry:
2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE is used as a fragrance ingredient for its strong aromatic properties, contributing to the scent profiles of various perfumes.
Used in Cosmetics Industry:
In the cosmetics industry, 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE is used as a flavoring agent to enhance the sensory experience of soaps and other cosmetic products.
Used in Pharmaceutical Synthesis:
2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE is utilized as a key intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new medicinal compounds.
Used in Organic Chemistry:
As an aromatic aldehyde, 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE is employed in organic chemistry for the synthesis of a variety of organic compounds, broadening its applications across different chemical sectors.

InChI:InChI=1/C14H12O2/c1-11-6-8-13(9-7-11)16-14-5-3-2-4-12(14)10-15/h2-10H,1H3

Upstream product

• 624-31-7 4-tolyl iodide 
• 90-02-8 salicylaldehyde 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 106-44-5 p-cresol 
• 89-98-5 2-chloro-benzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 106-38-7 para-bromotoluene 

Downstream Products

• 858954-31-1 N'-{(1E)-[2-(4-methylphenoxy)phenyl]methylene}-2-phenylacetohydrazide 
• 1048382-71-3 C₁₄H₁₂F₂O 
• 6279-07-8 2-methyl-9H-xanthene 
• 607-88-5 p-tolyl 2-hydroxybenzoate 
• 21905-72-6 methyl 2-(4-methylphenoxy)benzoate 
• 7320-51-6 2-methyldibenzofuran 
• 1285625-56-0 2-(4'-methylphenoxy)phenyltosylate 
• 35094-90-7 2-(4-methylphenoxy)phenol 
• 1290052-62-8 methyl 3-hydroxy-2-methylene-3-[2-(p-tolyloxy)phenyl]propanoate 
• 1290052-70-8 (Z)-methyl 2-bromomethyl-3-[2-(p-tolyloxy)phenyl]propenoate 

Relevant academic research and scientific papers

Novel β?hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies

In this study, a series of novel β?hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis methods. All the synthesized compounds were screened for anticancer activity against MCF-7 and U87 cells. Among them, compound 3l was appeared to be the most potent compound on both cancer cells; and IC50 dose was determined as 145 μM for MCF-7 cells and 6,6 μM for U87 cells. DNA ladder and Annexin V apoptotic marker tests were used and as a result, 3l caused the initiation of apoptosis on U87 cells. VDAC protein expression increased dramatically after U87 glioblastoma brain cancer cells were treated with compound 3l Additionally, the molecular modeling of these compounds was studied in FLT3 receptor, Estrogen receptor, and PARP2 receptor for the treatment of Acute Myeloid Leukemia (AML), breast cancer, and Glioblastoma (GBM) respectively. Their binding motifs and drug-like properties were investigated, and the results are highlighted in the discussion. Based on the results, compound 3l may have a potential drug candidate profile that can reverse the drug resistance profile.

Pyrimidine onium compound and application thereof

The invention relates to a pyrimidine onium compound, nitride oxides, salt of the nitride oxides and a composition comprising the compound. The invention further relates to an application of the compound to plant pest control.

An organocatalytic method for the synthesis of some novel xanthene derivatives by the intramolecular Friedel-Crafts reaction

An efficient organocatalytic method for the synthesis of new substituted 9-arylxanthenes (2a-2u) starting from diarylcarbinol compounds with an arenoxy group (1a-1u) has been developed using the intramolecular Friedel-Crafts reaction. The substrates were

Tert -Butoxide mediated cascade desulfonylation/arylation/hydrolysis of cyclic sulfonyimines using diaryliodonium salts: Synthesis of diaryl ether derivatives bearing a 2-aldehyde group

Cascades of cyclic sulfonyimines mediated by tBuOK with diaryliodonium salts has been developed, giving the diaryl ethers in good yields. Furthermore, bulky ortho-substituted diaryl ethers with an aldehyde group can be obtained easily in comparision with metal-catalyzed protocols.

Ligand-free catalytic system for the synthesis of diarylethers over Cu 2O/Cu-CNTs as heterogeneous reusable catalyst

Various substituted diarylether derivatives were prepared by using heterogeneous reusable Cu2O- and Cu-coated carbon nanotubes (Cu 2O/Cu-CNTs) as catalyst under ligand-free conditions, which provided good to excellent yields. The catalyst was characterized by TEM, XRD, and AAS analysis. The effects of solvent, base, and amount of catalyst for the O-arylation were investigated. The catalyst could be recovered by simple filtration from the reaction mixture without further treatment and reused several times with consistent catalytic activity. In addition, CNTs could also be recovered from the used Cu2O/Cu-CNTs by a simple acid treatment.

Cross dehydrogenative coupling via base-promoted homolytic aromatic substitution (BHAS): Synthesis of fluorenones and xanthones

Cross dehydrogenative coupling reactions occurring via base-promoted homolytic aromatic substitutions (BHASs) are reported. Fluorenones and xanthones are readily prepared via CDC starting with readily available ortho-formyl biphenyls and ortho-formyl biphenylethers, respectively. The commercially available and cheap tBuOOH is used as an oxidant. Initiation of the radical chain reaction is best achieved with small amounts of FeCp2 (0.1 or 1 mol %).

Metal-free oxidative coupling: Xanthone formation via direct annulation of 2-aryloxybenzaldehyde using tetrabutylammonium bromide as a promoter in aqueous medium

A metal-free intramolecular annulation of 2-aryloxybenzaldehydes to xanthones is disclosed, which proceeds through the direct oxidative coupling of an aldehyde C-H bond and aromatic C-H bonds using tetrabutylammonium bromide (TBAB) as a promoter in aqueous medium. This strategy works smoothly in the presence of both electron-donating and electron-withdrawing groups, and displays good tolerance towards catalytically reactive substituents, thus promising further functionalizations of xanthone products.

Palladium-catalyzed intramolecular C-H arylation of arenes using tosylates and mesylates as electrophiles

This paper describes a method for the palladium catalyzed intramolecular C-H arylation using tosylates and mesylates as electrophiles. The transformation is efficient for the synthesis of various heterocyclic motifs including furans, carbazoles, indoles, and lactams. Additionally, a protocol for the one-pot sequential tosylation/arylation of phenol derivatives is presented.

Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols

The first example of ligand-free copper-catalyzed O-arylation of nitroarenes with phenols was developed, achieving unsymmetrical diaryl ethers in moderate to excellent yields. This arylation proceeded smoothly without promotion of the ligands, and displayed great functional group compatibility. Thus, the method represents a new, facile, and cost-effective approach to access unsymmetrical diaryl ethers.

The coupling of arylboronic acids with nitroarenes catalyzed by rhodium

The coupling of arylboronic acids with electron-deficient nitroarenes was realized for the first time by using a rhodium(I) catalyst under an air atmosphere, achieving unsymmetrical diaryl ethers with yields ranging from poor to good. From a deuterium labeling experiment, the oxygen atom is derived from ambient water. The efficiency of this reaction was demonstrated by its compatibility with fluoro, bromo, chloro, and trifluoromethyl groups.