19434-35-6

Basic information

• Product Name: 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE
• Synonyms: 2-(P-TOLYLOXY)BENZALDEHYDE;2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE;2-(4-Methylphenoxy)benzaldehyde
• CAS NO: 19434-35-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 19434-35-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 52-54°
• Boiling Point: 316.5 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 0.000408mmHg at 25°C
• Refractive Index: 1.599
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE(19434-35-6)
• EPA Substance Registry System: 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE(19434-35-6)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 19434-35-6(Hazardous Substances Data)

Usage

General Description

2-(4-methylphenoxy)benzenecarbaldehyde, also known as m-tolylbenzaldehyde, is a chemical compound with the molecular formula C15H14O. It is an aromatic aldehyde that is commonly used as a fragrance ingredient and flavoring agent in the production of perfumes, soaps, and cosmetics. It is also used in the synthesis of pharmaceuticals and other organic compounds. The compound has a strong odor and is highly flammable, so it should be handled with care. Additionally, it may cause irritation to the eyes, skin, and respiratory system, and should be used in a well-ventilated area.

InChI:InChI=1/C14H12O2/c1-11-6-8-13(9-7-11)16-14-5-3-2-4-12(14)10-15/h2-10H,1H3

Upstream product

• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 106-38-7 para-bromotoluene 
• 106-44-5 p-cresol 
• 89-98-5 2-chloro-benzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 624-31-7 4-tolyl iodide 
• 90-02-8 salicylaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 858954-31-1 N'-{(1E)-[2-(4-methylphenoxy)phenyl]methylene}-2-phenylacetohydrazide 
• 1048382-71-3 C₁₄H₁₂F₂O 
• 1290052-70-8 (Z)-methyl 2-bromomethyl-3-[2-(p-tolyloxy)phenyl]propenoate 
• 1290052-62-8 methyl 3-hydroxy-2-methylene-3-[2-(p-tolyloxy)phenyl]propanoate 
• 35094-90-7 2-(4-methylphenoxy)phenol 
• 1285625-56-0 2-(4'-methylphenoxy)phenyltosylate 
• 7320-51-6 2-methyldibenzofuran 
• 607-88-5 p-tolyl 2-hydroxybenzoate 
• 21905-72-6 methyl 2-(4-methylphenoxy)benzoate 
• 6279-07-8 2-methyl-9H-xanthene 

Relevant articles and documents

Novel β?hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies

In this study, a series of novel β?hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis methods. All the synthesized compounds were screened for anticancer activity against MCF-7 and U87 cells. Among them, compound 3l was appeared to be the most potent compound on both cancer cells; and IC50 dose was determined as 145 μM for MCF-7 cells and 6,6 μM for U87 cells. DNA ladder and Annexin V apoptotic marker tests were used and as a result, 3l caused the initiation of apoptosis on U87 cells. VDAC protein expression increased dramatically after U87 glioblastoma brain cancer cells were treated with compound 3l Additionally, the molecular modeling of these compounds was studied in FLT3 receptor, Estrogen receptor, and PARP2 receptor for the treatment of Acute Myeloid Leukemia (AML), breast cancer, and Glioblastoma (GBM) respectively. Their binding motifs and drug-like properties were investigated, and the results are highlighted in the discussion. Based on the results, compound 3l may have a potential drug candidate profile that can reverse the drug resistance profile.

An organocatalytic method for the synthesis of some novel xanthene derivatives by the intramolecular Friedel-Crafts reaction

An efficient organocatalytic method for the synthesis of new substituted 9-arylxanthenes (2a-2u) starting from diarylcarbinol compounds with an arenoxy group (1a-1u) has been developed using the intramolecular Friedel-Crafts reaction. The substrates were

Ligand-free catalytic system for the synthesis of diarylethers over Cu 2O/Cu-CNTs as heterogeneous reusable catalyst

Various substituted diarylether derivatives were prepared by using heterogeneous reusable Cu2O- and Cu-coated carbon nanotubes (Cu 2O/Cu-CNTs) as catalyst under ligand-free conditions, which provided good to excellent yields. The catalyst was characterized by TEM, XRD, and AAS analysis. The effects of solvent, base, and amount of catalyst for the O-arylation were investigated. The catalyst could be recovered by simple filtration from the reaction mixture without further treatment and reused several times with consistent catalytic activity. In addition, CNTs could also be recovered from the used Cu2O/Cu-CNTs by a simple acid treatment.