21911-77-3

Basic information

• Product Name: Glycine, N-ethyl-N-phenyl-, ethyl ester
• Synonyms: ethyl (phenylethylamino)acetate;N-ethyl-N-phenyl-glycine ethyl ester;N-Aethyl-N-phenyl-glycin-aethylester;Aethylanilinoessigsaeure-aethylester;(Ethyl-phenyl-amino)-acetic acid ethyl ester;N-ethyl-N-phenylglycine ethyl ester;ethyl N-ethyl-N-phenylglycinate
• CAS NO: 21911-77-3
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 21911-77-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 177 - 178 °C (42 mmHg)
• CAS DataBase Reference: Glycine, N-ethyl-N-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-ethyl-N-phenyl-, ethyl ester(21911-77-3)
• EPA Substance Registry System: Glycine, N-ethyl-N-phenyl-, ethyl ester(21911-77-3)

Safety Data

• Hazardous Substances Data: 21911-77-3(Hazardous Substances Data)

Upstream product

• 613-97-8 N-methyl-N-ethylaniline 
• 623-48-3 ethyl iodoacetae 
• 623-73-4 diazoacetic acid ethyl ester 
• 91-66-7 N,N-diethylaniline 
• 201230-82-2 carbon monoxide 
• 103-69-5 N-ethyl-N-phenylamine 
• 626-35-7 nitroacetic acid ethyl ester 
• 122-52-1 triethyl phosphite 
• 98-80-6 phenylboronic acid 
• 109-92-2 ethyl vinyl ether 
• 105-36-2 ethyl bromoacetate 
• 62-53-3 aniline 
• 2216-92-4 N-phenylglycine ethyl ester 
• 425-75-2 trifluoromethanesulfonic acid ethyl ester 

Downstream Products

• 55932-12-2 phenyliminodiacetic acid diethyl ester 
• 65209-97-4 N-ethyl-N-phenylglycine 
• 21911-78-4 N-phenyl-N-ethylglycine hydrochloride 
• 100133-15-1 N-ethyl-N-phenyl-glycine hydrazide 
• 798570-59-9 2-(N-ethylphenylamino)acetamide 
• 120547-23-1 exo-7-(ethylphenylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 120662-11-5 endo-7-(ethylphenylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 120577-47-1 10-(ethylphenylamino)bicyclo<6.2.0>dec-10-en-9-one 
• 120547-27-5 endo-10-(ethylphenylamino)bicyclo<6.2.0>decan-9-one 

Relevant articles and documents

Design, synthesis of novel bisazo disperse dyes: Structure analysis and dyeing performance on PET

To achieve bisazo disperse dyes with better dyeing performances, novel bisazo disperse dyes based on butane-1,4-diyl bis(ethyl(phenyl)carbamate) were synthesized by coupling with diazonium salts. Butane-1,4-diyl bis(ethyl(phenyl)carbamate) was prepared by condensation of 1,4-butanediol and N-ethyl-N-phenylglycinoyl chloride. N-ethyl-N-phenylglycinoyl chloride was achieved from N-ethyl-N-phenylglycine, which was hydrolyzed from ethyl N-ethyl-N-phenylglycinate. Compared with previously reported bisazo disperse dyes’ low exhaustion, poor fastness performance or monotone color, constructed symmetrical bisazo disperse dyes exhibited excellent dyeing performance on polyethylene terephthalate (PET) fabrics, by introducing 1,4-butanediol as soft chain to lessen structure hardness of dye molecule and stronger hydrophobicity. Enhanced affinity between dye molecular and fiber was achieved by ester groups existing both in dye molecular and fiber, increased molecular size also enhanced stronger Van der Waals force and hydrogen bonding. Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance techniques (1H NMR) were used to confirm the structures of synthesized dyes. UV–Vis method was applied to estimate relationship between spectral properties and structures. Constructed bisazo disperse dyes were applied on polyethylene terephthalate (PET) fabric using conventional high temperature dyeing method under pressure, gave orange to blue shade with satisfying fastness properties. Quantum simulation was applied to provide a new guide line to evaluate structure-property relationship for dyestuffs.

KINASE INHIBITOR

The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

ADDITIVE COMPOSITION FOR CULTURE MEDIUM, ADDITIVE COMPOUND FOR CULTURE MEDIUM, AND METHOD FOR CULTURE OF CELLS OR TISSUE USING SAME

The present invention provides a medium additive composition containing a compound represented by the following formula (I), or a salt thereof: {wherein each symbol is as defined in the DESCRIPTION.}