21911-77-3

Basic information

• Product Name: Glycine, N-ethyl-N-phenyl-, ethyl ester
• Synonyms: ethyl (phenylethylamino)acetate;N-ethyl-N-phenyl-glycine ethyl ester;N-Aethyl-N-phenyl-glycin-aethylester;Aethylanilinoessigsaeure-aethylester;(Ethyl-phenyl-amino)-acetic acid ethyl ester;N-ethyl-N-phenylglycine ethyl ester;ethyl N-ethyl-N-phenylglycinate
• CAS NO: 21911-77-3
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 21911-77-3.mol

Chemical Properties

• Boiling Point: 177 - 178 °C (42 mmHg)
• CAS DataBase Reference: Glycine, N-ethyl-N-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-ethyl-N-phenyl-, ethyl ester(21911-77-3)
• EPA Substance Registry System: Glycine, N-ethyl-N-phenyl-, ethyl ester(21911-77-3)

Safety Data

• Hazardous Substances Data: 21911-77-3(Hazardous Substances Data)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 103-69-5 N-ethyl-N-phenylamine 
• 613-97-8 N-methyl-N-ethylaniline 
• 623-48-3 ethyl iodoacetae 
• 2216-92-4 N-phenylglycine ethyl ester 
• 425-75-2 trifluoromethanesulfonic acid ethyl ester 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 109-92-2 ethyl vinyl ether 
• 626-35-7 nitroacetic acid ethyl ester 
• 122-52-1 triethyl phosphite 
• 98-80-6 phenylboronic acid 
• 623-73-4 diazoacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 798570-59-9 2-(N-ethylphenylamino)acetamide 
• 100133-15-1 N-ethyl-N-phenyl-glycine hydrazide 
• 55932-12-2 phenyliminodiacetic acid diethyl ester 
• 120547-29-7 endo-9-(ethylphenylamino)bicyclo<5.2.0>nonan-8-one 
• 120547-20-8 9-(ethylphenylamino)bicyclo<5.2.0>non-9-en-8-one 
• 120547-27-5 endo-10-(ethylphenylamino)bicyclo<6.2.0>decan-9-one 
• 120577-47-1 10-(ethylphenylamino)bicyclo<6.2.0>dec-10-en-9-one 
• 120662-11-5 endo-7-(ethylphenylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 120547-23-1 exo-7-(ethylphenylamino)bicyclo<3.2.0>hept-2-en-6-one 
• 65209-97-4 N-ethyl-N-phenylglycine 

Relevant articles and documents

Design, synthesis of novel bisazo disperse dyes: Structure analysis and dyeing performance on PET

To achieve bisazo disperse dyes with better dyeing performances, novel bisazo disperse dyes based on butane-1,4-diyl bis(ethyl(phenyl)carbamate) were synthesized by coupling with diazonium salts. Butane-1,4-diyl bis(ethyl(phenyl)carbamate) was prepared by condensation of 1,4-butanediol and N-ethyl-N-phenylglycinoyl chloride. N-ethyl-N-phenylglycinoyl chloride was achieved from N-ethyl-N-phenylglycine, which was hydrolyzed from ethyl N-ethyl-N-phenylglycinate. Compared with previously reported bisazo disperse dyes’ low exhaustion, poor fastness performance or monotone color, constructed symmetrical bisazo disperse dyes exhibited excellent dyeing performance on polyethylene terephthalate (PET) fabrics, by introducing 1,4-butanediol as soft chain to lessen structure hardness of dye molecule and stronger hydrophobicity. Enhanced affinity between dye molecular and fiber was achieved by ester groups existing both in dye molecular and fiber, increased molecular size also enhanced stronger Van der Waals force and hydrogen bonding. Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance techniques (1H NMR) were used to confirm the structures of synthesized dyes. UV–Vis method was applied to estimate relationship between spectral properties and structures. Constructed bisazo disperse dyes were applied on polyethylene terephthalate (PET) fabric using conventional high temperature dyeing method under pressure, gave orange to blue shade with satisfying fastness properties. Quantum simulation was applied to provide a new guide line to evaluate structure-property relationship for dyestuffs.

Alpha-substituted-alpha-amino acid ester compound and preparation method thereof

The invention discloses an alpha-substituted-alpha-amino acid ester compound and a preparation method thereof. Aromatic amine and alkenyl ether are added into a reactor and dissolved in a solvent, a reaction is carried out under the action of a palladium catalyst, a ligand and an oxidizing agent, separation and purification are carried out, the alpha-substituted-alpha-amino acid ester compound is obtained, and the reaction formula of the preparation method is shown in the formula (I). According to the method, alkenyl ether and aromatic amine which are simple and easy to obtain are used as reaction raw materials to synthesize a series of alpha-substituted-alpha-amino-acid ester compounds, and the method has the advantages that the raw materials are simple and easy to obtain, operation is convenient, conditions are mild, step atom economy is high, substrate applicability is wide, and functional group tolerance is good.

Design, synthesis and biological evaluation of oxime lacking Psammaplin inspired chemical libraries as anti-cancer agents

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro. Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro.

KINASE INHIBITOR

The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

Transition-Metal-Free Three-Component Synthesis of Tertiary Aryl Amines from Nitro Compounds, Boronic Acids, and Trialkyl Phosphites

The synthesis of aromatic amines is of continuous interest in chemistry. An exceptionally versatile three-component reaction that directly transforms inexpensive nitro compounds, boronic acids, and trialkyl phosphites into tertiary aromatic amines has been realized. The reaction tolerates alkyl and aryl substituents on the nitro and boronic acid moieties, as well as functionalized phosphites. No transition-metal catalysis is required. The method is orthogonal to other classical metal-catalyzed syntheses since it tolerates the presence of halogens, and also permits the synthesis of functionalized compounds such as α-amino ester derivatives. (Figure presented.).

ADDITIVE COMPOSITION FOR CULTURE MEDIUM, ADDITIVE COMPOUND FOR CULTURE MEDIUM, AND METHOD FOR CULTURE OF CELLS OR TISSUE USING SAME

The present invention provides a medium additive composition containing a compound represented by the following formula (I), or a salt thereof: {wherein each symbol is as defined in the DESCRIPTION.}

Fused imidazole compounds with indoleamine 2,3-dioxygenase inhibition activity

The invention relates to fused imidazole compounds, and a preparation method and application thereof. The structure of the compounds is shown in a general formula I, wherein the definitions of each group are as described in the specification. The compounds are capable of selectively inhibiting indoleamine 2,3-dioxygenase (IDO). The compounds provided by the invention can be used as IDO inhibitorsfor the treatment and/or prevention of diseases with the pathological characteristics of IDO mediated tryptophan metabolism pathways, such as cancer, eye diseases, autoimmune diseases, psychological disorders, depression, anxiety and other diseases.

Access to α-Amino Acid Esters through Palladium-Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source

A novel and convenient palladium catalytic system for the synthesis of α-amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α-amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.

NH insertion reactions catalyzed by reusable water-soluble ruthenium(II)-hm-phenyloxazoline complex

A water-soluble Ru(II)-hm-pheox complex was efficiently catalyzed NH insertion of EDA with a broad class of amine derivatives in water/ether biphasic medium to deliver the biologically active precursors α-aminoester products with excellent yields (up to >99%). The products were separated by decantation and the catalyst was washed and reused several times (at least 8 times) without any specific loss of its catalytic activity. The plausible mechanism of the reaction was explained. Additionally, In case of ethylene diamine, the NH insertion product could be transformed to biological active piperazinone compound in high yield. The asymmetric version of this catalytic reaction is under investigation.

Polymer-supported ruthenium(II)/phenyloxazoline complex: Reusable and highly selective catalyst for N-H insertion reactions

A group of functionalized β-amino esters were successfully synthesized in excellent yields (> 99 %) via NH-insertion of ethyldiazoacetate into various amines catalyzed by porous-polymer-supported ruthenium(II)-pheox catalyst. The catalyst was readily recovered and reused at least five times without loss of its catalytic activity.