219123-54-3

Upstream product

• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 143884-27-9 (R)-5-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2,2-difluoro-hexanoic acid methyl ester 

Downstream Products

• 219123-52-1 (2R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-methyl-1-((R)-toluene-4-sulfinyl)-heptan-2-ol 
• 219123-57-6 (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(1R,5R)-4,4-difluoro-5-(2-methoxy-ethoxymethoxy)-1,5-dimethyl-6-((R)-toluene-4-sulfinyl)-hexyl]-7a-methyl-octahydro-indene 
• 197702-96-8 (2S,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal 
• 197702-98-0 (2S,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptan-1-ol 

Relevant academic research and scientific papers

Stereoselective synthesis and structural establishment of (25S)-24,24- difluoro-1α,25,26-trihydroxyvitamin D3, a major metabolite of 24,24- difluoro-1α,25-dihydroxyvitamin D3

(25S)-24,24-Difluoro-1α,25,26-trihydroxyvitamin D3 (3a) and its (25R)- epimer (3b), either of which is expected to be a major metabolite of 24,24- difluoro-1α,25-dihydroxyvitamin D3 (2), were synthesized. Asymmetric addition to β-ket