Stereoselective synthesis and structural establishment of (25S)-24,24- difluoro-1α,25,26-trihydroxyvitamin D3, a major metabolite of 24,24- difluoro-1α,25-dihydroxyvitamin D3

DOI: 10.1016/S0040-4020(98)00949-1

Source and publish data:

Tetrahedron p. 14705 - 14724 (1998)

Update date:2022-09-26

Topics:

Authors:

Iwasaki, Hiroshi

Hosotani, Ryuzo

Miyamoto, Yoichi

Nakano, Yoshio

Yamamoto, Keiko

Yamada, Sachiko

Shinki, Toshimasa

Suda, Tatsuo

Yamaguchi, Kentaro

Konno, Katsuhiro

Takayama, Hiroaki

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Article abstract of DOI:10.1016/S0040-4020(98)00949-1

(25S)-24,24-Difluoro-1α,25,26-trihydroxyvitamin D₃ (3a) and its (25R)- epimer (3b), either of which is expected to be a major metabolite of 24,24- difluoro-1α,25-dihydroxyvitamin D₃ (2), were synthesized. Asymmetric addition to β-ket

Full text of DOI:10.1016/S0040-4020(98)00949-1

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