219132-82-8

Basic information

• Product Name: 4-(4-methyl-1,4-diazepan-1-yl)aniline
• Synonyms: 4-(4-methyl-1,4-diazepan-1-yl)aniline
• CAS NO: 219132-82-8
• Molecular Formula: C₁₂H₁₉N₃
• Molecular Weight: 205.3
• Product Categories: aniline
• Mol File: 219132-82-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-methyl-1,4-diazepan-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methyl-1,4-diazepan-1-yl)aniline(219132-82-8)
• EPA Substance Registry System: 4-(4-methyl-1,4-diazepan-1-yl)aniline(219132-82-8)

Safety Data

• Hazardous Substances Data: 219132-82-8(Hazardous Substances Data)

Upstream product

• 220220-23-5 tert-butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 4318-37-0 1-Methylhomopiperazine 
• 350-46-9 4-Fluoronitrobenzene 
• 214124-83-1 1-(4-nitrophenyl)-[1,4]diazepane 
• 586-78-7 para-nitrophenyl bromide 
• 505-66-8 1,4-Diazacycloheptane 
• 223786-22-9 1-methyl-4-(4-nitro-phenyl)-[1,4]-diazepane 

Downstream Products

• 771584-87-3 3-((1E)-3-{[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}prop-1-en-1-yl)benzonitrile 
• 771584-73-7 7-({[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}methyl)-2-naphthonitrile 
• 771584-74-8 N-[(7-cyano-2-naphthyl)methyl]-N-[4-(4-methyl-1,4-diazepan-1-yl)phenyl]methanesulfonamide 
• 220220-38-2 N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide 
• 771584-77-1 N-[(7-cyano-2-naphthyl)methyl]-N',N'-dimethyl-N-[4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide 
• 771584-89-5 isopropyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-88-4 ethyl ({[(2E)-3-(3-cyanophenyl)prop-2-en-1-yl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-78-2 ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)carbamate 
• 714249-31-7 ethyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-91-9 ethyl ({((2E)-3-{3-[amino(imino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetate 
• 771584-76-0 tert-butyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)methylcarbamate 
• 771584-97-5 ({((2E)-3-{3-[amino(hydroxyimino)methyl]phenyl}prop-2-en-1-yl)[4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)acetic acid 
• 771584-75-9 tert-butyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)carbamate 

Relevant articles and documents

Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni

We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, Schistosoma mansoni. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads for further assessment and optimization.

Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors with Potent Antitumor Activity

Cyclin-dependent kinases (CDKs) are promising therapeutic targets for cancer therapy. Herein, we describe our efforts toward the discovery of a series of 5-chloro-N4-phenyl-N2-(pyridin-2-yl)pyrimidine-2,4-diamine derivatives as dual CDK6 and 9 inhibitors. Intensive structural modifications lead to the identification of compound 66 as the most active dual CDK6/9 inhibitor with balancing potency against these two targets and good selectivity over CDK2. Further biological studies revealed that compound 66 was directly bound to CDK6/9, resulting in suppression of their downstream signaling pathway and inhibition of cell proliferation by blocking cell cycle progression and inducing cellular apoptosis. More importantly, compound 66 significantly inhibited tumor growth in a xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment. Therefore, the above results are of great importance in the development of dual CDK6/9 inhibitors for cancer therapy.

8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND

Disclosed are 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one compounds, specifically represented by the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein A and R1-R7 are defined herein. Compounds having Formula I are Wee1 kinase inhibitors. Therefore, compounds of the disclosure may be used to treat diseases caused by abnormal Wee1 activity.