21922-62-3

Upstream product

• 53088-68-9 methyl 3-chlorophenylacetate 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 41904-39-6 3-chloro-benzeneacetyl chloride 
• 1878-65-5 3-chlorophenylacetic acid 

Downstream Products

• 258520-81-9 1-(3-chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 258520-90-0 (3-chloro-phenyl)-(6,7-dimethoxy-3,4-dihydro-isoquinolin-1-yl)-methanone 

Relevant academic research and scientific papers

Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.

Synthesis of 6,7-dimethoxy-1-halobenzyl-1,2,3,4-tetrahydroisoquinolines

Some 6,7-dimethoxy-1-halobenzyl-1,2,3,4-tetrahydroisoquinolines were synthesized from 2-(3,4-dimethoxyphenyl)ethylamine and halophenylacetic acids in three steps in good yield.