21945-72-2

Upstream product

• 576-22-7 2-Bromo-m-xylene 
• 100-52-7 benzaldehyde 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 1123-56-4 2,6-dimethylbenzaldehyde 
• 98-80-6 phenylboronic acid 

Downstream Products

• 130525-15-4 2,6-dimethyl-1-benzene 
• 21945-94-8 [2-(2,6-dimethyl-benzhydryloxy)-ethyl]-dimethyl-amine 
• 103395-16-0 (2,6-dimethylphenyl)(phenyl)methyl chloride 
• 1704-59-2 (2-{2-[(2,6-Dimethyl-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-dimethyl-amine 

Relevant academic research and scientific papers

Axial coordination of NHC ligands on dirhodium(II) complexes: Generation of a new family of catalysts

(Chemical Equation Presented) An efficient new methodology for the arylation of aldehydes is disclosed which uses dirhodium(II) catalysts and N-heterocyclic carbene (NHC) ligands. Complexes of Rh2(OAc) 4 with one and two NHCs attached on the axial positions were successfully isolated, fully characterized, and used as catalysts in the reaction. The saturated monocomplex ((NHC 5)Rh2(OAc)4) 31 was shown to be the most active catalyst and was particularly efficient in the arylation of alkyl aldehydes. DFT calculations support participation of complexes with one axial NHC in the reaction as the catalysts active species and indicate that hydrogen bonds involving dirhodium unit, reactants, and solvent (alcohol) play an important role on the reaction mechanism.

Suzuki-miyaura coupling of diarylmethyl carbonates with arylboronic acids: A new access to triarylmethanes

Suzuki-Miyaura coupling of diarylmethyl carbonates with arylboronic acids proceeded in the presence of [Pd(n3-C3H 5)CI]2-DPPPent (1,5- bis(diphenylphosphino)pentane) catalyst, yielding a variety of triarylmethanes.

Microwave irradiation as a high-speed tool for activation of sluggish aryl chlorides in Grignard reactions

Grignard reagents have been generated from reluctant aryl chlorides and bromides using controlled microwave heating to establish a safe, productive and reproducible method. In the synthesis of a novel HIV-1 protease inhibitor, microwave irradiation was both used to generate the starting arylmagnesium halide and to promote a subsequent Kumada coupling. Georg Thieme Verlag Stuttgart.