219506-75-9

Upstream product

• 3586-58-1 2-methylenebutyric acid 
• 100-51-6 benzyl alcohol 
• 51951-27-0 2-isopropoxyisoindoline-1,3-dione 
• 89295-32-9 2-(ethoxycarbonyl)prop-2-en-1-yl phenyl sulfone 
• 4390-96-9 2-ethylacryloyl chloride 

Downstream Products

• 219506-81-7 benzyl (2S)-2-(N-4-nitrobenzyloxycarbonylamino)-4-{[(2R,S)-2-(benzyloxycarbonyl)butyl]-(R,S)-N-(o-xylylenephosphoryl)-sulfonimidoyl}butanoate 
• 219506-80-6 benzyl (2S)-4-[(2R,S)-2-(benzyloxycarbonyl)butyl-(R,S)-sulfonimidoyl]-2-(N-4-nitrobenzyloxycarbonylamino)butanoate 
• 219506-79-3 (S)-4-(2-Benzyloxycarbonyl-butane-1-sulfinyl)-2-(4-nitro-benzyloxycarbonylamino)-butyric acid benzyl ester 
• 219506-77-1 (S)-4-(2-Benzyloxycarbonyl-butylsulfanyl)-2-(4-nitro-benzyloxycarbonylamino)-butyric acid benzyl ester 

Relevant academic research and scientific papers

Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals

A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β-fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron-neutral phosphine acts as the deoxygenation reagent.

Polyanionic polymers which enhance fusogenicity

The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.