219509-79-2

Usage

Uses

Used in Pharmaceutical Research:
1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is used as a research compound for its potential as a CNS depressant, providing insights into the development of new medications for central nervous system disorders.
Used in Drug Synthesis:
As an intermediate in the synthesis of various drugs, 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is used for its structural properties that can be further modified to create new pharmaceutical agents.
Used in Enzyme Inhibition:
1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is used as a selective inhibitor of certain enzymes, which can be instrumental in treating enzyme-related diseases and conditions.
Used in Anti-inflammatory Applications:
In the field of medicine, 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is used as an anti-inflammatory agent, potentially helping to reduce inflammation and associated symptoms in various conditions.
Used in Anti-cancer Applications:
1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is studied for its potential as an anti-cancer agent, with the aim of developing new treatments for cancer by targeting specific pathways and mechanisms involved in tumor growth and progression.

Upstream product

• 67-56-1 methanol 
• 79-22-1 methyl chloroformate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 50606-31-0 methyl piperazine-1-carboxylate 
• 873697-75-7 methyl piperazine-1,3-carboxylate hydrochloride 
• 1260098-49-4 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid methyl ester 
• 1391636-60-4 C₁₇H₂₃ClN₂O₄ 
• 253175-63-2 C₃₈H₄₂N₆O₁₀ 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Relevant academic research and scientific papers

Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis

Piperazine-containing compounds serve as one of the most important classes of compounds throughout all fields of chemistry. Alas, current synthetic methods have fallen short of providing a general method for the synthesis of highly decorated piperazine fragments. Herein, we present a site-selective approach to the C-H functionalization of existing piperazine compounds using photoredox catalysis. This manifold relies on the predictable differentiation of electronically distinct nitrogen centers within the piperazine framework, granting access to novel C-alkylated variants of the starting piperazines.

Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines

The present invention discloses aromatic heterocyclic derivatives and applications of the aromatic heterocyclic derivatives in medicines, and specifically provides a class of aromatic heterocyclic compounds or stereoisomers, geometric isomers, tautomers, racemic bodies, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the compounds. The present invention further discloses uses of the compounds or pharmaceutical compositions in drug preparation, wherein the drug is used for treatment of respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Optimization of a series of aminomethyl ketone diamine H3R antagonists to reduce the brain exposure by lowering the pKa, led to molecules with improved pharmacokinetic properties. Compounds 9, 19, and 25 had high affinity for human H3R and demonstrated in vivo H3R functional activity in the rat dipsogenia model. Compound 9 displayed modest wake-promoting activity in the rat EEG/EMG model.

Unsymmetrical tetrasubstituted ureas from tertiary carbamoylimidazole: Activation by AlMe3

An efficient and general method for the synthesis of unsymmetrical tetrasubstituted ureas from carbamoylimidazole is described. The conversion is achieved by the concurrent quarternization of the imidazole nitrogen and activation of amines with AlMe3. The Royal Society of Chemistry 2012.

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From these studies compound 2, BMS-262084, was identified as a potent and selective tryptase inhibitor which, when dosed intratracheally in ovalbumin-sensitized guinea pigs, reduced allergen-induced bronchoconstriction and inflammatory cell infiltration into the lung.

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.