219509-79-2

Basic information

• Product Name: 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate
• Synonyms: 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate
• CAS NO: 219509-79-2
• Molecular Formula: C₁₁H₂₀N₂O₄
• Molecular Weight: 244.2875
• Mol File: 219509-79-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate(219509-79-2)
• EPA Substance Registry System: 1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate(219509-79-2)

Safety Data

• Hazardous Substances Data: 219509-79-2(Hazardous Substances Data)

Usage

General Description

1-tert-Butyl 4-Methyl piperazine-1,4-dicarboxylate is a chemical compound that is commonly used in pharmaceutical research and as an intermediate in the synthesis of various drugs. It is a piperazine derivative, with a molecular structure consisting of a piperazine ring and two carboxylate groups. The tert-butyl and methyl groups in the compound contribute to its stability and solubility in organic solvents. It is also known for its potential as a CNS (central nervous system) depressant and as a selective inhibitor of certain enzymes, making it a valuable component in the development of new therapeutic agents. Additionally, this compound has been studied for its potential anti-inflammatory and anti-cancer properties, further highlighting its versatility and potential applications in medicine.

Upstream product

• 67-56-1 methanol 
• 79-22-1 methyl chloroformate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 50606-31-0 methyl piperazine-1-carboxylate 
• 1391636-60-4 C₁₇H₂₃ClN₂O₄ 
• 1260098-49-4 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid methyl ester 
• 873697-75-7 methyl piperazine-1,3-carboxylate hydrochloride 
• 253175-63-2 C₃₈H₄₂N₆O₁₀ 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Relevant articles and documents

Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis

Piperazine-containing compounds serve as one of the most important classes of compounds throughout all fields of chemistry. Alas, current synthetic methods have fallen short of providing a general method for the synthesis of highly decorated piperazine fragments. Herein, we present a site-selective approach to the C-H functionalization of existing piperazine compounds using photoredox catalysis. This manifold relies on the predictable differentiation of electronically distinct nitrogen centers within the piperazine framework, granting access to novel C-alkylated variants of the starting piperazines.

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Optimization of a series of aminomethyl ketone diamine H3R antagonists to reduce the brain exposure by lowering the pKa, led to molecules with improved pharmacokinetic properties. Compounds 9, 19, and 25 had high affinity for human H3R and demonstrated in vivo H3R functional activity in the rat dipsogenia model. Compound 9 displayed modest wake-promoting activity in the rat EEG/EMG model.

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From these studies compound 2, BMS-262084, was identified as a potent and selective tryptase inhibitor which, when dosed intratracheally in ovalbumin-sensitized guinea pigs, reduced allergen-induced bronchoconstriction and inflammatory cell infiltration into the lung.