873697-75-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl piperazine-1-carboxylate hydrochloride is used as a key intermediate for the synthesis of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its chemical properties allow it to be a reliable component in the formulation of various medications.
Used as a Building Block in Drug Synthesis:
In the realm of medicinal chemistry, Methyl piperazine-1-carboxylate hydrochloride is utilized as a building block for the synthesis of new drug candidates. Its structural features make it suitable for the creation of a wide range of biologically active molecules.
Used as a Reagent in Organic Synthesis:
Methyl piperazine-1-carboxylate hydrochloride also serves as a reagent in organic synthesis, facilitating various chemical reactions that are essential in the production of complex organic compounds.
Used as a Precursor for Heterocyclic Compounds:
Furthermore, it is used as a precursor in the preparation of various heterocyclic compounds, which are important in the field of organic chemistry and have applications in pharmaceuticals, agrochemicals, and other areas.
Used in Research and Development of Novel Pharmaceuticals:
Methyl piperazine-1-carboxylate hydrochloride is also employed as a research chemical, playing a crucial role in the exploration and development of innovative pharmaceuticals, thereby contributing to advancements in medical treatments and therapies.

Upstream product

• 142-64-3 piperazine dihydrochloride 
• 79-22-1 methyl chloroformate 
• 219509-79-2 1-(tert-butyl) 4-methyl piperazine-1,4-dicarboxylate 
• 110-85-0 piperazine 

Downstream Products

• 943769-02-6 C₁₄H₁₈FN₃O₄ 
• 873697-71-3 methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate 
• 50606-31-0 methyl piperazine-1-carboxylate 

Relevant academic research and scientific papers

1-Alkyl-1-methylpiperazine-1,4-diium salts: Synthetic, acid-base, XRD-analytical, FT-IR, FT-Raman spectral and quantum chemical study

We report the preparation and results of vibrational spectral analysis, which were obtained using both FT-IR and FT-Raman spectroscopy, for three 1-alkyl-1-methylpiperazine-1,4-diium salts (AMPSs), where alkyl is benzyl 4a, n-octadecyl 4b, and methyl 4c, respectively. These were prepared by multistep synthesis from piperazine. The acid-base study of AMPSs was performed and corresponding acid-base constants were obtained. Single crystals of AMPSs suitable for XRD-analysis were obtained and analyzed. The complete vibrational assignments of wavenumbers were made on the basis of a potential energy distribution. The HOMO and LUMO analysis was used to determine the charge transfer within the molecules. The calculated first hyperpolarizabilities of AMPSs 4a-4c are 48.34, 57.77 and 123.41 times that of urea. As can be seen from the MEP plots, the negative electrostatic potential regions are mainly localized over the chlorine and oxygen atoms for compounds 4a and 4b and chlorine and iodine atoms of compound 4c, and are possible sites for electrophilic attack.

Simplified procedure for general synthesis of monosubstituted piperazines-from a batch reaction vessel to a flow (microwave) reactor

We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.

Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines

The present invention discloses aromatic heterocyclic derivatives and applications of the aromatic heterocyclic derivatives in medicines, and specifically provides a class of aromatic heterocyclic compounds or stereoisomers, geometric isomers, tautomers, racemic bodies, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the compounds. The present invention further discloses uses of the compounds or pharmaceutical compositions in drug preparation, wherein the drug is used for treatment of respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).