219587-07-2Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some new S-substituted quinazolinones containing different heterocyclic rings
Al-Majidi, Suaad M. H.,Al-Khuzaie, Mohammed G. A.
, p. 756 - 762 (2015)
New thiazolidine, azetidine and tetrazole derivatives of 2-mercapto-3-phenyl-4(3H)-quinazolinone are synthesized via the conversation of ester derivative (2) of 2-mercapto-3-phenyl-4(3H)-quinazolinone to hydrazide (3) by the reaction with hydrazine hydrate followed by Schiff's bases (4-8) formation by reaction with different aromatic aldehydes. Finally, Schiff's bases reacted with (2-mercptoacetic acid, monochloroacetyl chloride and sodium azide) to form thiazolidine (9-13), azetidine (14-18) and tetrazole (19-23) derivatives, respectively. The structure of newly synthesized compounds were identified by spectral methods their [FTIR and some of them by 1H NMR, 13C NMR] and measurements some of its physical properties and some specific reactions. Furthermore were studied the effects of the preparing compounds on some strains of bacteria and fungicidal.
Synthesis and enantioselective cleavage of chiralic quinazoline carboxylic acid esters
Beyrich, Thorsten,Theiss
, p. 853 - 858 (2007/10/03)
The synthesis of chiralic propionic acid ethylesters of 3-alkyl-4-oxo- 2-thioxo-1,2,3,4-tetrahydroquinazolines was described and their chromatographic behaviour was investigated on the chiralic phases (S,S)- Whelk-01 and Chiralcel-OD-H. The enantioselective cleavage succeeded by means of lipase of Candida cylindracea (CCL, E.C. 3.1.1.3.), of pork liver esterase (PLE, E.C. 3.1.1.1.) and of the enzymes of screening set Chirazyme, too. The results pointed out that the modification at the C3-alkyl group has a significant influence to the cleavage rate and the enantioselectivity. The highest selectivity is to obtain in presence of π-electrons in the 3- substituent whereas voluminous aryl groups block up the effectiveness of the enzymes used.
