Synthesis and antimicrobial activity of some new S-substituted quinazolinones containing different heterocyclic rings

Article abstract of DOI:10.14233/ajchem.2015.18417

New thiazolidine, azetidine and tetrazole derivatives of 2-mercapto-3-phenyl-4(3H)-quinazolinone are synthesized via the conversation of ester derivative (2) of 2-mercapto-3-phenyl-4(3H)-quinazolinone to hydrazide (3) by the reaction with hydrazine hydrate followed by Schiff's bases (4-8) formation by reaction with different aromatic aldehydes. Finally, Schiff's bases reacted with (2-mercptoacetic acid, monochloroacetyl chloride and sodium azide) to form thiazolidine (9-13), azetidine (14-18) and tetrazole (19-23) derivatives, respectively. The structure of newly synthesized compounds were identified by spectral methods their [FTIR and some of them by ¹H NMR, ¹³C NMR] and measurements some of its physical properties and some specific reactions. Furthermore were studied the effects of the preparing compounds on some strains of bacteria and fungicidal.