219603-30-2

Upstream product

• 105452-39-9 (1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol 
• 90446-67-6 4-((tert-butyldimethylsilyl)oxy)benzoyl chloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 78324-14-8 tert-butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)benzoate 

Downstream Products

• 219603-31-3 (1R,2S)-(2-(4-hydroxybenzamido)-1-phenyl-1,3-propanediyl)bis(4-hydoxybenzoate) 

Relevant academic research and scientific papers

Synthesis and chiroptical properties of dendrimers elaborated from a chiral, nonracemic central core

Three generations of ester-terminated dendrimers have been constructed from (1R,2S)-2-amino-1-phenyl-1,3-propanediol, 1, as the central core. The chiroptical properties of the dendrimers were measured revealing that the molar rotations [Φ] of the dendrimers decreased with increasing dendrimer generation. Comparison to a series of substituted benzoate derivatives of 1 suggested that the decrease in rotation was a consequence of a steric effect upon the conformational equilibrium of the central core that increased with increasing dendrimer generation. The optical rotations of dendrimers 7-9 were also observed to be solvent and temperature dependent.