(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

Base Information

Chemical Name:(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)
CAS No.:219603-30-2
Molecular Formula:C₄₈H₆₇NO₈Si₃
Molecular Weight:870.318
Hs Code.:

Synonyms:(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

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Chemical Property of (1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

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Technology Process of (1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

There total 4 articles about (1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105452-39-9
(1R,2S)-(+)-2-amino-1-phenyl-1,3-propanediol

: 90446-67-6
4-((tert-butyldimethylsilyl)oxy)benzoyl chloride

: 219603-30-2
(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

Guidance literature:: With dmap; In pyridine; dichloromethane; at 0 - 20 ℃; for 14h;
DOI:10.1021/jo981508b

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 219603-30-2
(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / imidazole / dimethylformamide / 16 h / 60 °C

2: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 40 h / Ambient temperature

3: DMAP / CH₂Cl₂; pyridine / 14 h / 0 - 20 °C

With 1H-imidazole; dmap; oxalyl dichloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981508b

Reference yield:

: 78324-14-8
tert-butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)benzoate

: 219603-30-2
(1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate)

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 40 h / Ambient temperature

2: DMAP / CH₂Cl₂; pyridine / 14 h / 0 - 20 °C

With dmap; oxalyl dichloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981508b