219615-28-8Relevant academic research and scientific papers
New iridium complexes(III) bearing 2-phenylimidazo[4,5-f][1,10]-phenanthroline ligand: Synthesis, characterization, electrochemical and photoluminescence studies
Sahin, Cigdem,Sahin, Murat
, (2021)
Iridium complexes bearing 2-phenylimidazo[4,5-f]-[1,10]-phenanthroline with different substituents (-CH3, -CH(CH3)2, -OCH3, -C6H5) were synthesized and characterized. The effects of differe
Synthesis, Characterization, and Crystal Structure of a Chiral Platinum(II) Complex with 2-(4-Methoxy-Phenyl)-Imidazo[4, 5-f][l,10]-Phenanthroline Binding Interaction with DNA
Luo,Wang,Xu,Yang,Luo,Liu,Liang
, p. 679 - 684 (2017)
A new platinum(II) complex of [Pt(Chda)(4-MOPIP)]2+2Cl– · H2O (I) (Chda = cyclohexanediamine; 4-MOPIP = (4-methoxy-phenyl)-imidazo[4,5-f][l,10]-phenanthroline) has been synthesized by hydrothermal methods and characterized
A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift
Liu, Jin-Biao,Vellaisamy, Kasipandi,Li, Guodong,Yang, Chao,Wong, Suk-Yu,Leung, Chung-Hang,Pu, Shou-Zhi,Ma, Dik-Lung
, p. 3855 - 3858 (2018)
Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.
Development of a cyclometalated iridium complex with specific intramolecular hydrogen-bonding that acts as a fluorescent marker for the endoplasmic reticulum and causes photoinduced cell death
Mandal, Soumik,Poria, Dipak K.,Ghosh, Ritabrata,Ray, Partho Sarothi,Gupta, Parna
, p. 17463 - 17474 (2014)
Cyclometalated iridium complexes have important applications as phosphorescent probes for cellular imaging due to their photophysical properties. Moreover, these properties also make them potential candidates as photosensitizers for photodynamic therapy (PDT) of tumors and skin diseases. Treatment of MCF7 breast carcinoma cells with a heteroleptic phosphorescent cyclometalated iridium(iii) complex C2 followed by confocal imaging indicates that the complex selectively localizes and exhibits high fluorescence in the endoplasmic reticulum. In an unprecedented approach, systematic alteration of functional groups or the metal core in C2 to synthesize a series of iridium(iii) complexes (C1-C10) and an organometallic rhenium complex C11 with an imidazolyl modified phenanthroline ligand has indicated the functional groups and their interactions that are responsible for this selective localization. Remarkably, the exposure of the cells treated with C2 to irradiation at 405 nm for one hour led to membrane blebbing and cell death, demonstrating a photosensitizing property of the compound. This journal is
MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative
Zhen, Ni,Yang, Qingyuan,Zheng, Kangdi,Han, Zeping,Sun, Fenyong,Mei, Wenjie,Yu, Yongchun
, p. 158 - 167 (2016)
MicroRNAs are small non-coding RNAs with 18–22 nucleotides in length and have been proposed to function in various biological processes by targeting genes for post-transcriptional degradation via their 3′ untranslated region. Moreover, they have been sugg
Luminescent ruthenium(II)-para-cymene complexes of aryl substituted imidazo-1,10-phenanthroline as anticancer agents and the effect of remote substituents on cytotoxic activities
Ashok Kumar, S. K.,Banerjee, Subhasis,De, Sourav,Gauthaman, Ashna,Moorthy, Anbalagan,Paira, Priyankar,Selva Kumar, R.
, (2020/10/18)
Ruthenium complexes are currently significant attention in medicinal chemistry as they offer various properties which make them an appropriate choice for drug development. Herein, a series of ruthenium(II)-p-cymene-2-aryl-imidazo-1,10-phenanthroline derivatives have been prepared and characterised by elemental analysis, infrared, LC-mass and NMR techniques. The structural and chemical properties shows that Ru(II) complexes have got rigidity, planarity, aromaticity, hydrogen donating and accepting capability which aids both solubility and interaction with biomolecules. The binding strength of these complexes with DNA and BSA were found to be 104–106 M?1. The competitive displacement of ethidium bromide (EtBr) from DNA in the presence of complex reveals an intercalation or groove binding further this was supported by viscosity and in-silico studies. The cytotoxicity study of these Ru(II) complexes were conducted with two cancer cell lines (MDA-MB-231 and HeLa) and one human embryonic kidney cells (HEK-293). The study revealed that [(η6-p-cymene)RuCl (κ2-N,N-2-(4-fluorophenyl)-1H-imidazo[4,5-f][1,10]Phenanthroline].PF6 (4e), [(η6-p-cymene)RuCl(κ2-N,N-2-(4-bromophenyl)-1H-imidazo[4,5-f][1,10]Phenanthroline].PF6 (4f) and [(η6-p-cymene)RuCl(κ2-N,N-2-(4-nitrophenyl)-1H-imidazo[4,5-f][1,10]Phenanthro line].PF6 (4g) were found exhibit least inhibitory concentration (IC50) and high selectivity with respect to HeLa and MDA-MB-231. The activity of the Ru(II) complexes were position and substituents dependent.
Photo-induced mitochondrial DNA damage and NADH depletion by -NO2modified Ru(ii) complexes
Qi, Shuang,Jin, Zhihui,Jian, Yao,Hou, Yuanjun,Li, Chao,Zhao, Yao,Wang, Xuesong,Zhou, Qianxiong
supporting information, p. 4162 - 4165 (2021/05/04)
Two mitochondria-localized Ru(ii) complexes with photo-labile ligands were reported to exert one- and two-photon activatable anticancer activity through a dual-function mechanism, i.e. mitochondrial DNA covalent binding after photo-induced ligand dissociation and photo-catalyzed NADH depletion, thus displaying good activity towards cisplatin-resistant cancer cells under both normoxic and hypoxic conditions. This journal is
The synthesis and evaluation of the antitumor and antibacterial activity of two novel oxovanadium complexes
Cheng, Jianxin,Huang, Bin,Jiang, Guijjuan,Liao, Xiangwen,Wang, Jing,Wang, Jintao,Wang, Liqiang,Xiong, Yanshi
, p. 1016 - 1021 (2021/10/19)
Two novel oxovanadium(IV) complexes ([VO(hntdtsc)(BPIP)] and [VO(hntdtsc)(MOPIP)] (hntdtsc = 2-hydroxy-1-naphthaldehydethiosemicarbazone, BPIP = 2-(4-bromophenyl)-imidazo[4,5-f]-1,10-phenanthroline, MOPIP = 2-(4-methoxyphenyl)-imidazo[4,5-f]1,10-phenanthr
A Remote ‘Imidazole’-Based Ruthenium(II) Para-Cymene Pre-catalyst for the Selective Oxidation Reaction of Alkyl Arenes and Alcohols
Dutta, Manali,Bania, Kusum K.,Pratihar, Sanjay
, p. 926 - 932 (2020/03/05)
Herein we disclosed the use of a remote ‘imidazole’-based precatalyst [(para-cymene)RuII(L)Cl]+, C-1 where L=2-(4-substituted-phenyl)-1H-imidazo[4,5-f][1,10] phenanthroline) for the selective oxidation of a variety of alkyl arenes/heteroarenes and alcohols to their corresponding aldehydes or ketones in presence of tert-butyl hydroperoxide (TBHP). The remote ‘imidazole’ moiety present in the complex facilitates the activation of oxidant and subsequent generation of active species via the release of para-cymene from C-1, which in-turn was less effective without the ‘imidazole’ moiety. The mechanistic features of C-1 promoted oxidation of alkyl arenes were also assessed from spectroscopic, kinetic, and few control experiments. The substrate scope for C-1 promoted oxidation reaction was assessed based on the selective oxidation of 27-different alkyl arenes/heteroarenes and 25 different alcohols to their corresponding aldehydes/ketones in moderate to good yields.
Imidazole fused phenanthroline (PIP) ligands for the preparation of multimodal Re(i) and 99mTc(i) probes
Banevicius, Laura,Edem, Patricia E.,Mercanti, Natalie,Pitchumony, Tamil Selvi,Slikboer, Samantha R.,Valliant, John F.
, p. 14826 - 14836 (2020/11/11)
A small library of [2 + 1] 99mTc(i) complexes based on phenyl-imidazole-fused phenanthroline (PIP) ligands were synthesized and evaluated as multimodal molecular imaging probes. Using either a two-step or a one-pot synthesis method, 99mTc-PIP complexes containing N-methylimidazole as the monodentate ligand were prepared and isolated in good (54 to 89%) radiochemical yield, with the exception of one derivative bearing a strongly electron-withdrawing substituent. The stability of the [2 + 1] complexes was assessed in saline and in cysteine and histidine challenge studies, showing 6 hours stability, making them suitable for in vivo studies. In parallel, the Re(i) analogues were prepared as reference standards to verify the structure of the 99mTc complexes. The optical properties were consistent with other previously reported [2 + 1] type Re(i) complexes that have been used as cellular dyes and sensors. To facilitate the development of targeted derivatives, a tetrazine-PIP ligand was also synthesized. The 99mTc complex of the tetrazine PIP ligand effectively coupled to compounds containing a trans-cyclooctene (TCO) group including a TCO-albumin derivative, which was prepared as a model targeting molecule. An added benefit of the Re-PIP-Tz construct is that the emission from the metal complex was quenched by the presence of the tetrazine. Following the addition of TCO, there was a 70-fold increase in fluorescence emission, which can in future be leveraged during in vitro studies to reduce background signal. This journal is
