219677-67-5

Upstream product

• 57018-82-3 5'-O-dimethoxytrityladenosine 
• 14316-61-1 phenoxyacetic anhydride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 219677-68-6 6-N,2'-O,3'-O-tri(phenoxyacetyl)adenosine 
• 1054645-97-4 Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 6216-67-7 Adenosin-5'-phosphorsaeure-(N-benzyloxycarbonyl-L-leucinolat) 
• 688790-00-3 Phenoxy-acetic acid (2R,3R,4R,5R)-5-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Further studies with adenosine 5′-dithiophosphoromorpholidate. A convenient preparation of nucleoside phosphorodithioates by a 'triester' approach

Adenosine 5′-dithiophosphoromorpholidate 1c reacts with orthophosphate to give adenosine 5′-(α,α-dithio)diphosphate 3c but is not converted into adenosine 5′-phosphorodithioate 2c by acidic hydrolysis. A new approach to the synthesis of nucleoside phosphorodithioates is described.

Synthesis of peptidinol adenylates

Peptidinol adenylates were assembled by condensing the carboxyl group of N-blocked peptides with the alkylamino group of leucinol 5' adenosine phosphodiester. The latter was prepared as protected precursor from adenosine and leucinol by phosphite chemistry. The title compounds, which mimic aminoacyl adenylates, are designed to penetrate microorganisms via peptide permeases and to interfere with genetic translation.